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Sin3A Associated Protein 18kDa (SAP18)

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GIG38; 2HOR0202; Cell growth-inhibiting gene 38 protein; Sin3-associated polypeptide p18; Histone deacetylase complex subunit SAP18

Sin3A Associated Protein 18kDa (SAP18)
CCC K264
HGNC 10530
MGI 1277978
PubMed 9150135
RGD 1310388
UniProt O00422
Wiki SAP18
Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. SAP18 is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter.The predicted 153-amino acid SAP18 protein is 49% identical to a C. elegans SAP18 homolog. SAP18 has a molecular mass of 18 kD by SDS-PAGE.SAP18 directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression. They observed that SAP18 directs the formation of a repressive complex when tethered to the promoter. SAP18 was expressed in all tissues analyzed.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sin3A Associated Protein 18kDa (SAP18) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sin3A Associated Protein 18kDa (SAP18) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sin3A Associated Protein 18kDa (SAP18) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sin3A Associated Protein 18kDa (SAP18) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sin3A Associated Protein 18kDa (SAP18) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sin3A Associated Protein 18kDa (SAP18) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sin3A Associated Protein 18kDa (SAP18) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sin3A Associated Protein 18kDa (SAP18) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sin3A Associated Protein 18kDa (SAP18) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sin3A Associated Protein 18kDa (SAP18) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sin3A Associated Protein 18kDa (SAP18) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sin3A Associated Protein 18kDa (SAP18) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sin3A Associated Protein 18kDa (SAP18) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sin3A Associated Protein 18kDa (SAP18) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sin3A Associated Protein 18kDa (SAP18) ELISA Kit Customized Service Offer
  1. "Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex."Cell 89:357-364(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 13." Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "ASAP, a novel protein complex involved in RNA processing and apoptosis."Mol. Cell. Biol. 23:2981-2990(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core."RNA 11:1869-1883(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Human SAP18 mediates assembly of a splicing regulatory multiprotein complex via its ubiquitin-like fold."RNA 16:2442-2454(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Proteins associated with the exon junction complex also control the alternative splicing of apoptotic regulators."Mol. Cell. Biol. 32:954-967(2012) [PubMed] [Europe PMC] [Abstract]
  11. "Structure of SAP18: a ubiquitin fold in histone deacetylase complex assembly."Biochemistry 45:11974-11982(2006) [PubMed] [Europe PMC] [Abstract]