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Sin3A Associated Protein 30kDa (SAP30)

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Histone deacetylase complex subunit SAP30; Sin3 corepressor complex subunit SAP30

Sin3A Associated Protein 30kDa (SAP30)
CCC K263
HGNC 10532
MGI 1929129
PubMed 18225953
UniProt O75446
Wiki SAP30
SAP30 binds to the transcriptional corepressor mSin3 and is capable of mediating transcriptional repression via histone deacetylases. SAP30 also binds the N-CoR corepressor and is required for N-CoR-mediated repression by antagonist-bound estrogen receptor and the homeodomain protein Rpx, as well as N-CoR suppression of transactivation by the POU domain protein Pit1.
The human SAP30 protein contains 220 amino acids. the human SAP30 complex is active in deacetylating core histone octamers, but inactive in deacetylating nucleosomal histones due to the inability of the histone-binding proteins RBBP7 and RBBP4 to gain access to nucleosomal histones.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sin3A Associated Protein 30kDa (SAP30) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sin3A Associated Protein 30kDa (SAP30) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sin3A Associated Protein 30kDa (SAP30) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sin3A Associated Protein 30kDa (SAP30) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sin3A Associated Protein 30kDa (SAP30) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sin3A Associated Protein 30kDa (SAP30) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sin3A Associated Protein 30kDa (SAP30) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sin3A Associated Protein 30kDa (SAP30) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sin3A Associated Protein 30kDa (SAP30) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sin3A Associated Protein 30kDa (SAP30) ELISA Kit Customized Service Offer
  1. "SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex."Mol. Cell 1:1021-1031(1998) [PubMed] [Europe PMC] [Abstract]
  2. "SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors."Mol. Cell 2:33-42(1998) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract].
  4. "Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1."Genes Dev. 17:896-911(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  10. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  12. "Solution structure of a novel zinc finger motif in the SAP30 polypeptide of the Sin3 corepressor complex and its potential role in nucleic acid recognition."Nucleic Acids Res. 37:2142-2152(2009) [PubMed] [Europe PMC] [Abstract]