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SIN3 Homolog A (SIN3A)

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Paired amphipathic helix protein Sin3a; Histone deacetylase complex subunit Sin3a; Transcriptional corepressor Sin3a

SIN3 Homolog A (SIN3A)
CCC K261
HGNC 19353
MGI 107157
PubMed 22783022
RGD 1311598
UniProt Q96ST3
Wiki SIN3A
SIN3A is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex.The deduced 1,219-amino acid protein contains 4 paired amphipathic helix (PAH) domains.
Sin3a shares significant homology with yeast Sin3 and mouse Sin3b. The highest homology lies within the 4 PAH domains and between PAH3 and PAH4. Sin3a and Sin3b share less homology at their N termini.A multiprotein complex including HDAC1, HDAC2, and SIN3A was recruited to SP1 and SP3 sites of the LHR promoter and silenced SP1/SP3-driven LHR gene transcription. SIN3A interacted directly with both HDACs in the complex.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SIN3 Homolog A (SIN3A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SIN3 Homolog A (SIN3A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SIN3 Homolog A (SIN3A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SIN3 Homolog A (SIN3A) CLIA Kit Customized Service Offer
n/a ELISA Kit for SIN3 Homolog A (SIN3A) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SIN3 Homolog A (SIN3A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SIN3 Homolog A (SIN3A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SIN3 Homolog A (SIN3A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SIN3 Homolog A (SIN3A) CLIA Kit Customized Service Offer
n/a ELISA Kit for SIN3 Homolog A (SIN3A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SIN3 Homolog A (SIN3A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SIN3 Homolog A (SIN3A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SIN3 Homolog A (SIN3A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SIN3 Homolog A (SIN3A) CLIA Kit Customized Service Offer
n/a ELISA Kit for SIN3 Homolog A (SIN3A) ELISA Kit Customized Service Offer
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  6. "Transcriptional activation of human CYP17 in H295R adrenocortical cells depends on complex formation among p54(nrb)/NonO, protein-associated splicing factor, and SF-1, a complex that also participates in repression of transcription."Endocrinology 143:1280-1290(2002) [PubMed] [Europe PMC] [Abstract]
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  10. "Identification of a novel BRMS1-homologue protein p40 as a component of the mSin3A/p33(ING1b)/HDAC1 deacetylase complex."Biochem. Biophys. Res. Commun. 323:1216-1222(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  12. "SAP30L interacts with members of the Sin3A corepressor complex and targets Sin3A to the nucleolus."Nucleic Acids Res. 34:3288-3298(2006) [PubMed] [Europe PMC] [Abstract]
  13. "TOPORS functions as a SUMO-1 E3 ligase for chromatin-modifying proteins."J. Proteome Res. 6:3918-3923(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  15. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  19. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  20. "TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity."Nature 473:343-348(2011) [PubMed] [Europe PMC] [Abstract]
  21. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  22. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]