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AT-Rich Interactive Domain Containing Protein 3A (ARID3A)

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BRIGHT; DRIL1; DRIL3; E2FBP1; DRX; B-cell regulator of IgH transcription; Dead ringer-like protein 1; E2F-binding protein 1

AT-Rich Interactive Domain Containing Protein 3A (ARID3A)
CCC K254
HGNC 3031
MGI 1328360
PubMed 22172947
UniProt Q99856
Wiki ARID3A
ARID3A encodes a member of the ARID (AT-rich interaction domain) family of DNA binding proteins. It was found by homology to the Drosophila dead ringer gene, which is important for normal embryogenesis. Other ARID family members have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation, and possibly in chromatin structure modification.
The predicted protein is 79% identical to mouse Bright. The DNA-binding domain of DRIL1 is highly conserved, sharing 97% and 79% identity with the DNA-binding domain of Bright and DRI, respectively. Northern and dot blot analyses revealed that DRIL1 was expressed as a 4.4-kb mRNA in all tissues tested.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant AT-Rich Interactive Domain Containing Protein 3A (ARID3A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to AT-Rich Interactive Domain Containing Protein 3A (ARID3A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to AT-Rich Interactive Domain Containing Protein 3A (ARID3A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for AT-Rich Interactive Domain Containing Protein 3A (ARID3A) CLIA Kit Customized Service Offer
n/a ELISA Kit for AT-Rich Interactive Domain Containing Protein 3A (ARID3A) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant AT-Rich Interactive Domain Containing Protein 3A (ARID3A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to AT-Rich Interactive Domain Containing Protein 3A (ARID3A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to AT-Rich Interactive Domain Containing Protein 3A (ARID3A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for AT-Rich Interactive Domain Containing Protein 3A (ARID3A) CLIA Kit Customized Service Offer
n/a ELISA Kit for AT-Rich Interactive Domain Containing Protein 3A (ARID3A) ELISA Kit Customized Service Offer
  1. "The human dead ringer/bright homolog, DRIL1: cDNA cloning, gene structure, and mapping to D19S886, a marker on 19p13.3 that is strictly linked to the Peutz-Jeghers syndrome."Genomics 51:288-292(1998) [PubMed] [Europe PMC] [Abstract]
  2. "A novel E2F binding protein with Myc-type HLH motif stimulates E2F-dependent transcription by forming a heterodimer."Oncogene 17:853-865(1998) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "A functional screen identifies hDRIL1 as an oncogene that rescues RAS-induced senescence."Nat. Cell Biol. 4:148-153(2002) [PubMed] [Europe PMC] [Abstract]
  6. "E2FBP1/DRIL1, an AT-rich interaction domain-family transcription factor, is regulated by p53."Mol. Cancer Res. 1:438-444(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Induction of immunoglobulin heavy-chain transcription through the transcription factor Bright requires TFII-I."Mol. Cell. Biol. 26:4758-4768(2006) [PubMed] [Europe PMC] [Abstract]
  9. "REKLES is an ARID3-restricted multifunctional domain."J. Biol. Chem. 282:15768-15777(2007) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  15. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  16. "Solution NMR structure of the ARID domain of human AT-rich interactive domain-containing protein 3A: a human cancer protein interaction network target."Proteins 78:2170-2175(2010) [PubMed] [Europe PMC] [Abstract]