AT-Rich Interactive Domain Containing Protein 5B (ARID5B)

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MRF2; DESRT; MRF1-like protein; Modulator recognition factor 2

AT-Rich Interactive Domain Containing Protein 5B (ARID5B)
The deduced 743-amino acid protein has a calculated molecular mass of 83 kD and contains a central ARID domain. Mouse and human ARID5B share 82% identity over a 246-amino acid stretch that includes the ARID domain. Northern blot analysis detected a 9.0-kb transcript expressed in mouse lung, heart, small intestine, kidney, muscle, and brain. RT-PCR detected expression in most organs examined.
Lahoud et al. (2001) determined that the ARID domain of mouse Arid5b bound a (TAA)9 repeat. Excess unlabeled (TAA)9 competed with radiolabeled (TAA)9 for binding with the ARID domain, but excess unlabeled GC-containing nonspecific oligonucleotide did not.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant AT-Rich Interactive Domain Containing Protein 5B (ARID5B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to AT-Rich Interactive Domain Containing Protein 5B (ARID5B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to AT-Rich Interactive Domain Containing Protein 5B (ARID5B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for AT-Rich Interactive Domain Containing Protein 5B (ARID5B) CLIA Kit Customized Service Offer
n/a ELISA Kit for AT-Rich Interactive Domain Containing Protein 5B (ARID5B) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant AT-Rich Interactive Domain Containing Protein 5B (ARID5B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to AT-Rich Interactive Domain Containing Protein 5B (ARID5B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to AT-Rich Interactive Domain Containing Protein 5B (ARID5B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for AT-Rich Interactive Domain Containing Protein 5B (ARID5B) CLIA Kit Customized Service Offer
n/a ELISA Kit for AT-Rich Interactive Domain Containing Protein 5B (ARID5B) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant AT-Rich Interactive Domain Containing Protein 5B (ARID5B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to AT-Rich Interactive Domain Containing Protein 5B (ARID5B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to AT-Rich Interactive Domain Containing Protein 5B (ARID5B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for AT-Rich Interactive Domain Containing Protein 5B (ARID5B) CLIA Kit Customized Service Offer
n/a ELISA Kit for AT-Rich Interactive Domain Containing Protein 5B (ARID5B) ELISA Kit Customized Service Offer
  1. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "The novel Mrf-2 DNA-binding domain recognizes a five-base core sequence through major and minor-groove contacts."Biochem. Biophys. Res. Commun. 258:326-331(1999) [PubMed] [Europe PMC] [Abstract]
  6. "DNA-binding properties of ARID family proteins."Nucleic Acids Res. 33:66-80(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Genetic variations of Mrf-2/ARID5B confer risk of coronary atherosclerosis in the Japanese population."Int. Heart J. 49:313-327(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Germline genomic variants associated with childhood acute lymphoblastic leukemia."Nat. Genet. 41:1001-1005(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia."Nat. Genet. 41:1006-1010(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Verification of the susceptibility loci on 7p12.2, 10q21.2, and 14q11.2 in precursor B-cell acute lymphoblastic leukemia of childhood."Blood 115:1765-1767(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Replication analysis confirms the association of ARID5B with childhood B-cell acute lymphoblastic leukemia."Haematologica 95:1608-1611(2010) [PubMed] [Europe PMC] [Abstract]
  12. "ARID5B SNP rs10821936 is associated with risk of childhood acute lymphoblastic leukemia in blacks and contributes to racial differences in leukemia incidence."Leukemia 24:894-896(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Genome-wide association study of childhood acute lymphoblastic leukemia in Korea."Leuk. Res. 34:1271-1274(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Genetic landscape of high hyperdiploid childhood acute lymphoblastic leukemia."Proc. Natl. Acad. Sci. U.S.A. 107:21719-21724(2010) [PubMed] [Europe PMC] [Abstract]
  15. "PKA-dependent regulation of the histone lysine demethylase complex PHF2-ARID5B."Nat. Cell Biol. 13:668-675(2011) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  17. "A novel DNA-binding motif shares structural homology to DNA replication and repair nucleases and polymerases."Nat. Struct. Biol. 5:959-964(1998) [PubMed] [Europe PMC] [Abstract]
  18. "Dynamics of the Mrf-2 DNA-binding domain free and in complex with DNA."Biochemistry 40:9142-9150(2001) [PubMed] [Europe PMC] [Abstract]
  19. "Determination of the three-dimensional structure of the Mrf2-DNA complex using paramagnetic spin labeling."Biochemistry 46:4943-4950(2007) [PubMed] [Europe PMC] [Abstract]