FYN Oncogene Related To SRC/FGR/YES (FYN)

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SLK; SYN; c-Fyn; Src-like kinase

FYN Oncogene Related To SRC/FGR/YES (FYN)
FYN encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. Fyn is a tyrosine specific phospho-transferase that is a member of the Src family of tyrosine protein kinases.Fyn is primarily localized to the cytoplasmic leaflet of the plasma membrane, where it phosphorylates tyrosine residues on key targets involved in a variety of different signaling pathways. Tyrosine phosphorylation of target proteins by Fyn serves to either regulate target protein activity, and/or to generate a binding site on the target protein that recruits other signaling molecules.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPK247Hu01 Recombinant FYN Oncogene Related To SRC/FGR/YES (FYN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAK247Hu01 Polyclonal Antibody to FYN Oncogene Related To SRC/FGR/YES (FYN) WB; IHC; ICC; IP.
MAK247Hu21 Monoclonal Antibody to FYN Oncogene Related To SRC/FGR/YES (FYN) WB; IHC; ICC; IP.
Assay Kits SEK247Hu ELISA Kit for FYN Oncogene Related To SRC/FGR/YES (FYN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPK247Mu01 Recombinant FYN Oncogene Related To SRC/FGR/YES (FYN) Positive Control; Immunogen; SDS-PAGE; WB.
RPK247Mu02 Recombinant FYN Oncogene Related To SRC/FGR/YES (FYN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAK247Mu01 Polyclonal Antibody to FYN Oncogene Related To SRC/FGR/YES (FYN) WB; IHC; ICC; IP.
PAK247Mu02 Polyclonal Antibody to FYN Oncogene Related To SRC/FGR/YES (FYN) WB; IHC; ICC; IP.
Assay Kits SEK247Mu ELISA Kit for FYN Oncogene Related To SRC/FGR/YES (FYN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant FYN Oncogene Related To SRC/FGR/YES (FYN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to FYN Oncogene Related To SRC/FGR/YES (FYN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to FYN Oncogene Related To SRC/FGR/YES (FYN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for FYN Oncogene Related To SRC/FGR/YES (FYN) CLIA Kit Customized Service Offer
n/a ELISA Kit for FYN Oncogene Related To SRC/FGR/YES (FYN) ELISA Kit Customized Service Offer
  1. "Isolation and oncogenic potential of a novel human src-like gene."Mol. Cell. Biol. 6:4195-4201(1986) [PubMed] [Europe PMC] [Abstract]
  2. "Yes-related protooncogene, syn, belongs to the protein-tyrosine kinase family."Proc. Natl. Acad. Sci. U.S.A. 83:5459-5463(1986) [PubMed] [Europe PMC] [Abstract]
  3. "Human p59fyn(T) regulates OKT3-induced calcium influx by a mechanism distinct from PIP2 hydrolysis in Jurkat T cells."J. Immunol. 154:1136-1145(1995) [PubMed] [Europe PMC] [Abstract]
  4. "Human protein factory for converting the transcriptome into an in vitro-expressed proteome." Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "In vivo phosphorylation and membrane association of the fyn proto-oncogene product in IM-9 human lymphoblasts."Oncogene 5:1313-1319(1990) [PubMed] [Europe PMC] [Abstract]
  8. "Regulation of the p59fyn protein tyrosine kinase by the CD45 phosphotyrosine phosphatase."Eur. J. Immunol. 22:1173-1178(1992) [PubMed] [Europe PMC] [Abstract]
  9. "Src-homology 3 domain of protein kinase p59fyn mediates binding to phosphatidylinositol 3-kinase in T cells."Proc. Natl. Acad. Sci. U.S.A. 90:7366-7370(1993) [PubMed] [Europe PMC] [Abstract]
  10. "Dual myristylation and palmitylation of Src family member p59fyn affects subcellular localization."J. Biol. Chem. 269:16701-16705(1994) [PubMed] [Europe PMC] [Abstract]
  11. "p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulation."Proc. Natl. Acad. Sci. U.S.A. 92:8891-8895(1995) [PubMed] [Europe PMC] [Abstract]
  12. "Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes."J. Biol. Chem. 272:5915-5920(1997) [PubMed] [Europe PMC] [Abstract]
  13. "Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production."Proc. Natl. Acad. Sci. U.S.A. 94:7493-7498(1997) [PubMed] [Europe PMC] [Abstract]
  14. "A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth."Cell 94:625-634(1998) [PubMed] [Europe PMC] [Abstract]
  15. "Altered expression of tyrosine kinases of the Src and Syk families in human T-cell leukemia virus type 1-infected T-cell lines."J. Virol. 73:3709-3717(1999) [PubMed] [Europe PMC] [Abstract]
  16. "Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity."Oncogene 18:5413-5422(1999) [PubMed] [Europe PMC] [Abstract]
  17. "Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation."J. Exp. Med. 191:1591-1604(2000) [PubMed] [Europe PMC] [Abstract]
  18. "T-cell receptor antagonists induce Vav phosphorylation by selective activation of Fyn kinase."Proc. Natl. Acad. Sci. U.S.A. 97:10923-10929(2000) [PubMed] [Europe PMC] [Abstract]
  19. "Activated Fyn phosphorylates alpha-synuclein at tyrosine residue 125."Biochem. Biophys. Res. Commun. 280:1085-1092(2001) [PubMed] [Europe PMC] [Abstract]
  20. "The ORF3 protein of hepatitis E virus binds to Src homology 3 domains and activates MAPK."J. Biol. Chem. 276:42389-42400(2001) [PubMed] [Europe PMC] [Abstract]
  21. "Tyrosine phosphorylation of p190 RhoGAP by Fyn regulates oligodendrocyte differentiation."J. Neurobiol. 49:62-78(2001) [PubMed] [Europe PMC] [Abstract]
  22. "Fyn is essential for tyrosine phosphorylation of Csk-binding protein/phosphoprotein associated with glycolipid-enriched microdomains in lipid rafts in resting T cells."J. Immunol. 169:2813-2817(2002) [PubMed] [Europe PMC] [Abstract]
  23. "p250GAP, a neural RhoGAP protein, is associated with and phosphorylated by Fyn."Biochem. Biophys. Res. Commun. 306:151-155(2003) [PubMed] [Europe PMC] [Abstract]
  24. "Regulation of TRPC6 channel activity by tyrosine phosphorylation."J. Biol. Chem. 279:18887-18894(2004) [PubMed] [Europe PMC] [Abstract]
  25. "Phosphorylation of DCC by Fyn mediates Netrin-1 signaling in growth cone guidance."J. Cell Biol. 167:687-698(2004) [PubMed] [Europe PMC] [Abstract]
  26. "Fyn and PTP-PEST-mediated regulation of Wiskott-Aldrich syndrome protein (WASp) tyrosine phosphorylation is required for coupling T cell antigen receptor engagement to WASp effector function and T cell activation."J. Exp. Med. 199:99-112(2004) [PubMed] [Europe PMC] [Abstract]
  27. "Unc119, a novel activator of Lck/Fyn, is essential for T cell activation."J. Exp. Med. 199:369-379(2004) [PubMed] [Europe PMC] [Abstract]
  28. "Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation."Oncogene 23:7990-8000(2004) [PubMed] [Europe PMC] [Abstract]
  29. "Fyn phosphorylates human MAP-2c on tyrosine 67."J. Biol. Chem. 280:1962-1970(2005) [PubMed] [Europe PMC] [Abstract]
  30. "Regulation of ultraviolet B-induced phosphorylation of histone H3 at serine 10 by Fyn kinase."J. Biol. Chem. 280:2446-2454(2005) [PubMed] [Europe PMC] [Abstract]
  31. "Negative regulation of the E3 ubiquitin ligase itch via Fyn-mediated tyrosine phosphorylation."Mol. Cell 21:135-141(2006) [PubMed] [Europe PMC] [Abstract]
  32. "Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survival."Cell Death Differ. 14:368-377(2007) [PubMed] [Europe PMC] [Abstract]
  33. "Regulation of protein arginine methyltransferase 8 (PRMT8) activity by its N-terminal domain."J. Biol. Chem. 282:36444-36453(2007) [PubMed] [Europe PMC] [Abstract]
  34. "Specific phosphorylation of p120-catenin regulatory domain differently modulates its binding to RhoA."Mol. Cell. Biol. 27:1745-1757(2007) [PubMed] [Europe PMC] [Abstract]
  35. "Regulation of FynT function by dual domain docking on PAG/Cbp."J. Biol. Chem. 283:2773-2783(2008) [PubMed] [Europe PMC] [Abstract]
  36. "Neph1, a component of the kidney slit diaphragm, is tyrosine-phosphorylated by the Src family tyrosine kinase and modulates intracellular signaling by binding to Grb2."J. Biol. Chem. 283:9177-9186(2008) [PubMed] [Europe PMC] [Abstract]
  37. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  38. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  39. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  40. "Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract]
  41. "Phosphorylation of nephrin triggers Ca2+ signaling by recruitment and activation of phospholipase C-{gamma}1."J. Biol. Chem. 284:8951-8962(2009) [PubMed] [Europe PMC] [Abstract]
  42. "Semaphorin3A signaling mediated by Fyn-dependent tyrosine phosphorylation of collapsin response mediator protein 2 at tyrosine 32."J. Biol. Chem. 284:27393-27401(2009) [PubMed] [Europe PMC] [Abstract]
  43. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  44. "Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm."J. Biol. Chem. 285:10122-10129(2010) [PubMed] [Europe PMC] [Abstract]
  45. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  46. "T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice."J. Clin. Invest. 121:4758-4774(2011) [PubMed] [Europe PMC] [Abstract]
  47. "Crystal structure of the SH3 domain in human Fyn; comparison of the three-dimensional structures of SH3 domains in tyrosine kinases and spectrin."EMBO J. 12:2617-2624(1993) [PubMed] [Europe PMC] [Abstract]
  48. "High-resolution crystal structures of tyrosine kinase SH3 domains complexed with proline-rich peptides."Nat. Struct. Biol. 1:546-551(1994) [PubMed] [Europe PMC] [Abstract]
  49. "Structural and thermodynamic characterization of the interaction of the SH3 domain from Fyn with the proline-rich binding site on the p85 subunit of PI3-kinase."Biochemistry 35:15646-15653(1996) [PubMed] [Europe PMC] [Abstract]
  50. "Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain."Cell 85:931-942(1996) [PubMed] [Europe PMC] [Abstract]
  51. "Solution structure and peptide binding of the SH3 domain from human Fyn."Structure 4:705-714(1996) [PubMed] [Europe PMC] [Abstract]
  52. "The SH2 domain from the tyrosine kinase Fyn in complex with a phosphotyrosyl peptide reveals insights into domain stability and binding specificity."Structure 5:1313-1323(1997) [PubMed] [Europe PMC] [Abstract]
  53. "SAP couples Fyn to SLAM immune receptors."Nat. Cell Biol. 5:155-160(2003) [PubMed] [Europe PMC] [Abstract]
  54. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]