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Small Ubiquitin Related Modifier Protein 4 (SUMO4)

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IDDM5; SMT3H4; SUMO-4; SMT3 Suppressor Of Mif Two 3 Homolog 4; Small ubiquitin-like protein 4

Small Ubiquitin Related Modifier Protein 4 (SUMO4)
CCC K246
HGNC 21181
PubMed 15123604
UniProt Q6EEV6
Wiki SUMO4
SUMO4 is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene.
SUMO4 carrying the met55 variant was associated with elevated levels of activated heat-shock factor transcription factors as compared with val55, and that the levels of NF-kappa-B were suppressed to an identical degree. The authors confirmed a single sumoylation site in the DNA-binding domain of HSF2 at lysine-82.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Small Ubiquitin Related Modifier Protein 4 (SUMO4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Small Ubiquitin Related Modifier Protein 4 (SUMO4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Small Ubiquitin Related Modifier Protein 4 (SUMO4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Small Ubiquitin Related Modifier Protein 4 (SUMO4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Small Ubiquitin Related Modifier Protein 4 (SUMO4) ELISA Kit Customized Service Offer
  1. "A M55V polymorphism in a novel SUMO gene (SUMO-4) differentially activates heat shock transcription factors and is associated with susceptibility to type I diabetes mellitus."J. Biol. Chem. 279:27233-27238(2004) [PubMed] [Europe PMC] [Abstract]
  2. "A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes." Nat. Genet. 36:837-841(2004) [PubMed] [Europe PMC] [Abstract]
  3. Erratum Nat. Genet. 36:1024-1024(2004)
  4. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "A proline-90 residue unique to SUMO-4 prevents maturation and sumoylation."Biochem. Biophys. Res. Commun. 337:517-520(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress."Biochem. Biophys. Res. Commun. 337:1308-1318(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes."Nat. Genet. 37:110-111(2005) [PubMed] [Europe PMC] [Abstract]
  9. ErratumNat. Genet. 37:328-328(2004)
  10. "Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes."Nat. Genet. 37:111-112(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes."Nat. Genet. 37:112-112(2005) [PubMed] [Europe PMC] [Abstract]