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A Disintegrin And Metalloprotease 12 (ADAM12)

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MCMP; MCMPMltna; MLTN; MLTNA; Meltrin Alpha; Disintegrin and metalloproteinase domain-containing protein 12

A Disintegrin And Metalloprotease 12 (ADAM12)
CCC K242
HGNC 190
MGI 105378
PubMed 18342566
RGD 1583652
UniProt O43184
Wiki ADAM12
ADAM12 encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene has two alternatively spliced transcripts: a shorter secreted form and a longer membrane-bound form. Similarly to myogenin, a marker of early muscle differentiation, mouse meltrin-alpha is expressed in neonatal muscle and bone, and its expression increases dramatically in response to the induction of differentiation. Immunocytochemical localization and functional expression studies suggested that meltrin-alpha may be involved in myotube formation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPK242Hu01 Recombinant A Disintegrin And Metalloprotease 12 (ADAM12) Positive Control; Immunogen; SDS-PAGE; WB.
EPK242Hu61 Eukaryotic A Disintegrin And Metalloprotease 12 (ADAM12) Positive Control; Immunogen; SDS-PAGE; WB.
APK242Hu61 Active A Disintegrin And Metalloprotease 12 (ADAM12) Cell culture; Activity Assays.
Antibodies PAK242Hu01 Polyclonal Antibody to A Disintegrin And Metalloprotease 12 (ADAM12) WB; IHC; ICC; IP.
MAK242Hu21 Monoclonal Antibody to A Disintegrin And Metalloprotease 12 (ADAM12) WB; IHC; ICC; IP.
Assay Kits SEK242Hu ELISA Kit for A Disintegrin And Metalloprotease 12 (ADAM12) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant A Disintegrin And Metalloprotease 12 (ADAM12) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to A Disintegrin And Metalloprotease 12 (ADAM12) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to A Disintegrin And Metalloprotease 12 (ADAM12) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for A Disintegrin And Metalloprotease 12 (ADAM12) CLIA Kit Customized Service Offer
n/a ELISA Kit for A Disintegrin And Metalloprotease 12 (ADAM12) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant A Disintegrin And Metalloprotease 12 (ADAM12) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to A Disintegrin And Metalloprotease 12 (ADAM12) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to A Disintegrin And Metalloprotease 12 (ADAM12) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for A Disintegrin And Metalloprotease 12 (ADAM12) CLIA Kit Customized Service Offer
n/a ELISA Kit for A Disintegrin And Metalloprotease 12 (ADAM12) ELISA Kit Customized Service Offer
  1. "A novel, secreted form of human ADAM 12 (meltrin alpha) provokes myogenesis in vivo."J. Biol. Chem. 273:157-166(1998) [PubMed] [Europe PMC] [Abstract]
  2. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Human ADAM 12 (meltrin alpha) is an active metalloprotease."J. Biol. Chem. 273:16993-16997(1998) [PubMed] [Europe PMC] [Abstract]
  6. "The cysteine-rich domain of human ADAM 12 supports cell adhesion through syndecans and triggers signaling events that lead to beta1 integrin-dependent cell spreading."J. Cell Biol. 149:1143-1156(2000) [PubMed] [Europe PMC] [Abstract]
  7. "The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells."J. Biol. Chem. 278:16844-16851(2003) [PubMed] [Europe PMC] [Abstract]
  8. "FLRG, a new ADAM12-associated protein, modulates osteoclast differentiation."Biol. Cell 97:577-588(2005) [PubMed] [Europe PMC] [Abstract]
  9. "RACK1, a new ADAM12 interacting protein. Contribution to liver fibrogenesis."J. Biol. Chem. 283:26000-26009(2008) [PubMed] [Europe PMC] [Abstract]
  10. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma."Hum. Mutat. 32:E2148-E2175(2011) [PubMed] [Europe PMC] [Abstract]