A Disintegrin And Metalloprotease 11 (ADAM11)
[Edit]MDC; Metalloproteinase-Like,Disintegrin-like,Cysteine-Rich Protein; Disintegrin and metalloproteinase domain-containing protein 11
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ADAM11 encodes a member of the ADAM (a disintegrin and metalloprotease) protein family.This gene represents a candidate tumor supressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping.
ADAM11encoded a 524-amino acid metalloproteinase-like, disintegrin-like, and cysteine-rich (MDC) protein with sequence similarity to members of the snake-venom metalloprotease/disintegrin family and guinea-pig sperm-surface protein PH-30. These proteins have been implicated in cell-cell or cell-extracellular matrix interactions. Rearrangements in both tumors involved multiple exons and disrupted the coding region of the gene.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant A Disintegrin And Metalloprotease 11 (ADAM11) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to A Disintegrin And Metalloprotease 11 (ADAM11) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to A Disintegrin And Metalloprotease 11 (ADAM11) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for A Disintegrin And Metalloprotease 11 (ADAM11) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for A Disintegrin And Metalloprotease 11 (ADAM11) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant A Disintegrin And Metalloprotease 11 (ADAM11) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to A Disintegrin And Metalloprotease 11 (ADAM11) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to A Disintegrin And Metalloprotease 11 (ADAM11) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for A Disintegrin And Metalloprotease 11 (ADAM11) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for A Disintegrin And Metalloprotease 11 (ADAM11) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant A Disintegrin And Metalloprotease 11 (ADAM11) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to A Disintegrin And Metalloprotease 11 (ADAM11) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to A Disintegrin And Metalloprotease 11 (ADAM11) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for A Disintegrin And Metalloprotease 11 (ADAM11) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for A Disintegrin And Metalloprotease 11 (ADAM11) | ELISA Kit Customized Service Offer |
- "Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain."Biochem. J. 334:93-98(1998) [PubMed] [Europe PMC] [Abstract]
- "A novel metalloprotease/disintegrin-like gene at 17q21.3 is somatically rearranged in two primary breast cancers."Nat. Genet. 5:151-157(1993) [PubMed] [Europe PMC] [Abstract]
- "Human metalloprotease/disintegrin-like (MDC) gene: exon-intron organization and alternative splicing."Cytogenet. Cell Genet. 68:39-44(1995) [PubMed] [Europe PMC] [Abstract]
- "An unappreciated role for RNA surveillance."Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
- "Core signaling pathways in human pancreatic cancers revealed by global genomic analyses." Science 321:1801-1806(2008) [PubMed] [Europe PMC] [Abstract]