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Biogenesis Of Lysosomal Organelles Complex 1, Subunit 2 (BLOC1S2)

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BLOS2; CEAP; Centrosome-associated protein; Centrosome Protein Oncogene

Biogenesis Of Lysosomal Organelles Complex 1, Subunit 2 (BLOC1S2)
CCC K238
HGNC 20984
MGI 1920939
PubMed 15261680
RGD 1306551
UniProt Q6QNY1
Wiki BLOC1S2
BLOC1S2 is a component of the ubiquitously expressed BLOC1 multisubunit protein complex. BLOC1 is required for normal biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules.
BLOS2 contains coiled-coil regions and has a calculated molecular mass of 16 kD. Western blot analysis detected endogenous HeLa cell BLOS2 at an apparent molecular mass of 18 kD.BLOS2 as a subunit of BLOC1. Other BLOC1 subunits identified were pallidin, muted, dysbindin (DTNBP1), cappuccino, snapin (SNAPAP), BLOC1S1, and BLOC1S3. Coimmunoprecipitation and yeast 2-hybrid analyses confirmed that these proteins interact within the BLOC1 complex.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Biogenesis Of Lysosomal Organelles Complex 1, Subunit 2 (BLOC1S2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Biogenesis Of Lysosomal Organelles Complex 1, Subunit 2 (BLOC1S2) Monoclonal Antibody Customized Service Offer
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Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Biogenesis Of Lysosomal Organelles Complex 1, Subunit 2 (BLOC1S2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Biogenesis Of Lysosomal Organelles Complex 1, Subunit 2 (BLOC1S2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Biogenesis Of Lysosomal Organelles Complex 1, Subunit 2 (BLOC1S2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Biogenesis Of Lysosomal Organelles Complex 1, Subunit 2 (BLOC1S2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Biogenesis Of Lysosomal Organelles Complex 1, Subunit 2 (BLOC1S2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Biogenesis Of Lysosomal Organelles Complex 1, Subunit 2 (BLOC1S2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Biogenesis Of Lysosomal Organelles Complex 1, Subunit 2 (BLOC1S2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Biogenesis Of Lysosomal Organelles Complex 1, Subunit 2 (BLOC1S2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Biogenesis Of Lysosomal Organelles Complex 1, Subunit 2 (BLOC1S2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Biogenesis Of Lysosomal Organelles Complex 1, Subunit 2 (BLOC1S2) ELISA Kit Customized Service Offer
  1. "Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1)."J. Biol. Chem. 279:28393-28401(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization of Ceap-11 and Ceap-16, two novel splicing-variant-proteins, associated with centrosome, microtubule aggregation and cell proliferation."J. Mol. Biol. 343:71-82(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "BLOC-1 is required for cargo-specific sorting from vacuolar early endosomes toward lysosome-related organelles."Mol. Biol. Cell 18:768-780(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "Assembly and architecture of biogenesis of lysosome-related organelles complex-1 (BLOC-1)."J. Biol. Chem. 287:5882-5890(2012) [PubMed] [Europe PMC] [Abstract]
  9. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]