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Mitotic Arrest Deficient 2 Like Protein 2 (MAD2L2)

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MAD2B; REV7; Mitotic spindle assembly checkpoint protein MAD2B

Mitotic Arrest Deficient 2 Like Protein 2 (MAD2L2)
CCC K212
HGNC 6764
MGI 1919140
PubMed 17719540
UniProt Q9UI95
Wiki MAD2L2
MAD2L2 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L2 is a homolog of MAD2L1.
The predicted 211-amino acid MAD2B protein shares 24% and 26% sequence identity with yeast Mad2 and human MAD2L1, respectively, in the conserved regions. RT-PCR analysis revealed that both human MAD2 homologs were expressed at similar high levels in a panel of cell lines. Further binding analyses determined that the interaction of MAD2L2 with ADAM9 is mediated through a proline-rich SH3-ligand domain of ADAM9. Northern blot analysis detected 1.35-kb MAD2L2 transcripts in all tissues tested, with highest expression in testis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitotic Arrest Deficient 2 Like Protein 2 (MAD2L2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitotic Arrest Deficient 2 Like Protein 2 (MAD2L2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitotic Arrest Deficient 2 Like Protein 2 (MAD2L2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitotic Arrest Deficient 2 Like Protein 2 (MAD2L2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitotic Arrest Deficient 2 Like Protein 2 (MAD2L2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitotic Arrest Deficient 2 Like Protein 2 (MAD2L2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitotic Arrest Deficient 2 Like Protein 2 (MAD2L2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitotic Arrest Deficient 2 Like Protein 2 (MAD2L2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitotic Arrest Deficient 2 Like Protein 2 (MAD2L2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitotic Arrest Deficient 2 Like Protein 2 (MAD2L2) ELISA Kit Customized Service Offer
  1. "Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2-beta."Biochem. J. 343:673-680(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization of MAD2B and other mitotic spindle checkpoint genes."Genomics 58:181-187(1999) [PubMed] [Europe PMC] [Abstract]
  3. "A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2."J. Biol. Chem. 275:4391-4397(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Inhibition of Cdh1-APC by the MAD2-related protein MAD2L2: a novel mechanism for regulating Cdh1."Genes Dev. 15:1759-1764(2001) [PubMed] [Europe PMC] [Abstract]
  8. "MAD2B is an inhibitor of the anaphase-promoting complex."Genes Dev. 15:1765-1770(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7."J. Biol. Chem. 276:35644-35651(2001) [PubMed] [Europe PMC] [Abstract]
  10. "Impairment of MAD2B-PRCC interaction in mitotic checkpoint defective t(X;1)-positive renal cell carcinomas."Proc. Natl. Acad. Sci. U.S.A. 98:13808-13813(2001) [PubMed] [Europe PMC] [Abstract]
  11. "A bacterial effector targets Mad2L2, an APC inhibitor, to modulate host cell cycling."Cell 130:611-623(2007) [PubMed] [Europe PMC] [Abstract]
  12. "Hepatocellular carcinoma-associated gene 2 interacts with MAD2L2."Mol. Cell. Biochem. 304:297-304(2007) [PubMed] [Europe PMC] [Abstract]
  13. "Rev7/MAD2B links c-Jun N-terminal protein kinase pathway signaling to activation of the transcription factor Elk-1."Mol. Cell. Biol. 27:2861-2869(2007) [PubMed] [Europe PMC] [Abstract]
  14. "MAD2B, a novel TCF4-binding protein, modulates TCF4-mediated epithelial-mesenchymal transdifferentiation."J. Biol. Chem. 284:19613-19622(2009) [PubMed] [Europe PMC] [Abstract]
  15. "The mitotic arrest deficient protein MAD2B interacts with the small GTPase RAN throughout the cell cycle."PLoS ONE 4:E7020-E7020(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers."Cell 142:967-980(2010) [PubMed] [Europe PMC] [Abstract]
  17. "CAMP (C13orf8, ZNF828) is a novel regulator of kinetochore-microtubule attachment."EMBO J. 30:130-144(2011) [PubMed] [Europe PMC] [Abstract]
  18. "Crystal structure of human REV7 in complex with a human REV3 fragment and structural implication of the interaction between DNA polymerase zeta and REV1."J. Biol. Chem. 285:12299-12307(2010) [PubMed] [Europe PMC] [Abstract]