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Core Binding Factor Alpha Subunit 2 Translocated To 2 (CBFa2T2)

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EHT; MTGR1; ZMYND3; p85; ETO homologous on chromosome 20; MTG8-like protein; MTG8-related protein 1; Myeloid translocation-related protein 1

Core Binding Factor Alpha Subunit 2 Translocated To 2 (CBFa2T2)
CCC K188
HGNC 1536
MGI 1333833
PubMed 20520637
RGD 1309088
UniProt O43439
Wiki CBFA2T2
In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation.
CBFA2T2 binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.The putative EHT protein is approximately 65% identical to ETO/MTG8 and approximately 24% identical to an ETO Drosophila homolog, Nervy.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Core Binding Factor Alpha Subunit 2 Translocated To 2 (CBFa2T2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Core Binding Factor Alpha Subunit 2 Translocated To 2 (CBFa2T2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Core Binding Factor Alpha Subunit 2 Translocated To 2 (CBFa2T2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Core Binding Factor Alpha Subunit 2 Translocated To 2 (CBFa2T2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Core Binding Factor Alpha Subunit 2 Translocated To 2 (CBFa2T2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Core Binding Factor Alpha Subunit 2 Translocated To 2 (CBFa2T2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Core Binding Factor Alpha Subunit 2 Translocated To 2 (CBFa2T2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Core Binding Factor Alpha Subunit 2 Translocated To 2 (CBFa2T2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Core Binding Factor Alpha Subunit 2 Translocated To 2 (CBFa2T2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Core Binding Factor Alpha Subunit 2 Translocated To 2 (CBFa2T2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Core Binding Factor Alpha Subunit 2 Translocated To 2 (CBFa2T2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Core Binding Factor Alpha Subunit 2 Translocated To 2 (CBFa2T2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Core Binding Factor Alpha Subunit 2 Translocated To 2 (CBFa2T2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Core Binding Factor Alpha Subunit 2 Translocated To 2 (CBFa2T2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Core Binding Factor Alpha Subunit 2 Translocated To 2 (CBFa2T2) ELISA Kit Customized Service Offer
  1. "EHT, a new member of the MTG8/ETO gene family, maps on 20q11 region and is deleted in acute myeloid leukemias."Blood 92:3481-3484(1998) [PubMed] [Europe PMC] [Abstract]
  2. "The AML1-MTG8 leukemic fusion protein forms a complex with a novel member of the MTG8(ETO/CDR) family, MTGR1."Mol. Cell. Biol. 18:846-858(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Structure and expression pattern of a human MTG8/ETO family gene, MTGR1."Gene 241:287-295(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family."Genomics 52:332-341(1998) [PubMed] [Europe PMC] [Abstract]
  8. "The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t(16; 21)-positive myeloid malignancies."Oncogene 21:6703-6712(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]