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Pescadillo Homolog 1 (PES1)

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Pescadillo Homolog 1 (PES1)
CCC K173
HGNC 8848
MGI 1890613
PubMed 22820289
UniProt O00541
Wiki PES1
PES1 is abnormally elevated in malignant tumors of astrocytic origin. It is a strongly conserved gene containing a BRCT domain that is essential for the activity of this gene product. The gene plays a crucial role in cell proliferation and may be necessary for oncogenic transformation and tumor progression.The deduced 588-amino acid PES1 protein is 74% identical to the zebrafish sequence. The authors noted the presence of a highly acidic region at the C terminus and that the protein has an alpha-helix structure. Immunoblot analysis showed that PES1 is expressed as an unmodified 72-kD protein and a SUMO1-modified 92-kD protein. In situ hybridization analysis revealed wide and high expression of Pes1 in embryonic mouse brain and spinal cord. Pes1 expression was upregulated in malignant, late-passage mouse astrocytes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPK173Hu01 Recombinant Pescadillo Homolog 1 (PES1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAK173Hu01 Polyclonal Antibody to Pescadillo Homolog 1 (PES1) WB; IHC; ICC; IP.
MAK173Hu21 Monoclonal Antibody to Pescadillo Homolog 1 (PES1) WB; IHC; ICC; IP.
Assay Kits SEK173Hu ELISA Kit for Pescadillo Homolog 1 (PES1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pescadillo Homolog 1 (PES1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pescadillo Homolog 1 (PES1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pescadillo Homolog 1 (PES1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pescadillo Homolog 1 (PES1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pescadillo Homolog 1 (PES1) ELISA Kit Customized Service Offer
  1. "Insertional mutagenesis in zebrafish identifies two novel genes, pescadillo and dead eye, essential for embryonic development."Genes Dev. 10:3141-3155(1996) [PubMed] [Europe PMC] [Abstract]
  2. "A genome annotation-driven approach to cloning the human ORFeome."Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Pescadillo, a novel cell cycle regulatory protein abnormally expressed in malignant cells."J. Biol. Chem. 276:6656-6665(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Yeast Pescadillo is required for multiple activities during 60S ribosomal subunit synthesis."RNA 8:626-636(2002) [PubMed] [Europe PMC] [Abstract]
  7. ErratumRNA 8:851-851(2002)
  8. "Functional proteomic analysis of human nucleolus."Mol. Biol. Cell 13:4100-4109(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation."J. Cell Biol. 170:367-378(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Dominant-negative Pes1 mutants inhibit ribosomal RNA processing and cell proliferation via incorporation into the PeBoW-complex."Nucleic Acids Res. 34:3030-3043(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Interdependence of Pes1, Bop1, and WDR12 controls nucleolar localization and assembly of the PeBoW complex required for maturation of the 60S ribosomal subunit."Mol. Cell. Biol. 27:3682-3694(2007) [PubMed] [Europe PMC] [Abstract]
  12. "The BRCT domain of mammalian Pes1 is crucial for nucleolar localization and rRNA processing."Nucleic Acids Res. 35:789-800(2007) [PubMed] [Europe PMC] [Abstract]
  13. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  17. "Solution structure of the BRCT domain from human pescadillo homolog 1."Submitted (OCT-2007) to the PDB data bank