Leucine Rich Repeat LGI Family, Member 2 (LGI2)

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LGIL2; LGI1-like protein 2; Leucine-rich glioma-inactivated protein 2

Leucine Rich Repeat LGI Family, Member 2 (LGI2)
Lgi2 was expressed at low levels in most brain regions with high levels in the pyriform cortex and thalamic reticular nucleus. Lgi2 was secreted in transfected 293T cells. Immunofluorescence microscopy localized Lgi2 to discrete intracellular compartments, consistent with its presence in ER, Golgi bodies, and vesicles.
The deduced 542-amino acid protein shares 58% identity with LGI1. RT-PCR ELISA detected highest expression of LGI2 in heart, lung, kidney, and ovary, intermediate expression in liver and pancreas, low expression in brain and spleen, and little to no expression in skeletal muscle, testis, and spinal cord. Intermediate expression was detected in most specific brain regions examin

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Leucine Rich Repeat LGI Family, Member 2 (LGI2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Leucine Rich Repeat LGI Family, Member 2 (LGI2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Leucine Rich Repeat LGI Family, Member 2 (LGI2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Leucine Rich Repeat LGI Family, Member 2 (LGI2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Leucine Rich Repeat LGI Family, Member 2 (LGI2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Leucine Rich Repeat LGI Family, Member 2 (LGI2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Leucine Rich Repeat LGI Family, Member 2 (LGI2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Leucine Rich Repeat LGI Family, Member 2 (LGI2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Leucine Rich Repeat LGI Family, Member 2 (LGI2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Leucine Rich Repeat LGI Family, Member 2 (LGI2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Leucine Rich Repeat LGI Family, Member 2 (LGI2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Leucine Rich Repeat LGI Family, Member 2 (LGI2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Leucine Rich Repeat LGI Family, Member 2 (LGI2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Leucine Rich Repeat LGI Family, Member 2 (LGI2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Leucine Rich Repeat LGI Family, Member 2 (LGI2) ELISA Kit Customized Service Offer
  1. "The LGI1 gene involved in lateral temporal lobe epilepsy belongs to a new subfamily of leucine-rich repeat proteins."FEBS Lett. 519:71-76(2002) [PubMed] [Europe PMC] [Abstract]
  2. "A common protein interaction domain links two recently identified epilepsy genes."Hum. Mol. Genet. 11:1757-1762(2002) [PubMed] [Europe PMC] [Abstract]
  3. "The novel EPTP repeat defines a superfamily of proteins implicated in epileptic disorders."Trends Biochem. Sci. 27:441-444(2002) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins."DNA Res. 8:179-187(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]