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Leucine Rich Repeat LGI Family, Member 3 (LGI3)

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LGIL4; LGI1-like protein 4; Leucine-rich glioma-inactivated protein 3

Leucine Rich Repeat LGI Family, Member 3 (LGI3)
CCC K166
HGNC 18711
MGI 2182619
PubMed 20461023
RGD 1311079
UniProt Q8N145
The deduced 549-amino acid protein contains a N-terminal signal peptide, a putative transmembrane region, and 1 partial and 4 complete leucine-rich repeats (LRRs). The LRRs are flanked on both sides by cysteine-rich regions, and the N-terminal cysteine-rich region contains a motif conserved in LGIs. LGI3 shares significant similarity with LGI1, LGI2, and LGI4. Semiquantitative PCR detected LGI3 expression in all tissues examined, with highest levels in brain and lung.
By in situ hybridization of adult mouse brain, Senechal et al. (2005) showed that Lgi3 was expressed at low levels in most brain regions with high levels in the facial nerve nucleus. Lgi3 was secreted in transfected 293T cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPK166Hu01 Recombinant Leucine Rich Repeat LGI Family, Member 3 (LGI3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAK166Hu01 Polyclonal Antibody to Leucine Rich Repeat LGI Family, Member 3 (LGI3) WB; IHC; ICC; IP.
MAK166Hu21 Monoclonal Antibody to Leucine Rich Repeat LGI Family, Member 3 (LGI3) WB; IHC; ICC; IP.
Assay Kits SEK166Hu ELISA Kit for Leucine Rich Repeat LGI Family, Member 3 (LGI3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPK166Mu01 Recombinant Leucine Rich Repeat LGI Family, Member 3 (LGI3) Positive Control; Immunogen; SDS-PAGE; WB.
RPK166Mu02 Recombinant Leucine Rich Repeat LGI Family, Member 3 (LGI3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAK166Mu01 Polyclonal Antibody to Leucine Rich Repeat LGI Family, Member 3 (LGI3) WB; IHC; ICC; IP.
PAK166Mu02 Polyclonal Antibody to Leucine Rich Repeat LGI Family, Member 3 (LGI3) WB; IHC; ICC; IP.
Assay Kits SEK166Mu ELISA Kit for Leucine Rich Repeat LGI Family, Member 3 (LGI3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Leucine Rich Repeat LGI Family, Member 3 (LGI3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Leucine Rich Repeat LGI Family, Member 3 (LGI3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Leucine Rich Repeat LGI Family, Member 3 (LGI3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Leucine Rich Repeat LGI Family, Member 3 (LGI3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Leucine Rich Repeat LGI Family, Member 3 (LGI3) ELISA Kit Customized Service Offer
  1. "The LGI1 gene involved in lateral temporal lobe epilepsy belongs to a new subfamily of leucine-rich repeat proteins."FEBS Lett. 519:71-76(2002) [PubMed] [Europe PMC] [Abstract]
  2. "A common protein interaction domain links two recently identified epilepsy genes."Hum. Mol. Genet. 11:1757-1762(2002) [PubMed] [Europe PMC] [Abstract]
  3. "The novel EPTP repeat defines a superfamily of proteins implicated in epileptic disorders."Trends Biochem. Sci. 27:441-444(2002) [PubMed] [Europe PMC] [Abstract]
  4. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]