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A Disintegrin And Metalloprotease 22 (ADAM22)

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MDC2; Disintegrin And Metalloproteinase Domain-Containing Protein 22; Metalloproteinase-Like,Disintegrin-Like,And Cysteine-Rich Protein 2

A Disintegrin And Metalloprotease 22 (ADAM22)
CCC K165
HGNC 201
MGI 1340046
PubMed 20089912
UniProt Q9P0K1
Wiki ADAM22
ADAM22 is a member of the ADAM family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis.
Three-prime RACE yielded products corresponding to 2 MDC2 mRNAs, MDC2-alpha and -beta, in both mouse and human. MDC2-alpha encodes a predicted 859-amino acid protein. The shorter transcript, MDC2-beta, results from exon skipping and encodes an 823-amino acid protein. The MDC2-alpha protein shares 56% and 51% sequence similarity with MDC and MDC3, respectively.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPK165Hu01 Recombinant A Disintegrin And Metalloprotease 22 (ADAM22) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAK165Hu01 Polyclonal Antibody to A Disintegrin And Metalloprotease 22 (ADAM22) WB; IHC; ICC; IP.
MAK165Hu21 Monoclonal Antibody to A Disintegrin And Metalloprotease 22 (ADAM22) WB; IHC; ICC; IP.
Assay Kits SEK165Hu ELISA Kit for A Disintegrin And Metalloprotease 22 (ADAM22) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant A Disintegrin And Metalloprotease 22 (ADAM22) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to A Disintegrin And Metalloprotease 22 (ADAM22) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to A Disintegrin And Metalloprotease 22 (ADAM22) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for A Disintegrin And Metalloprotease 22 (ADAM22) CLIA Kit Customized Service Offer
n/a ELISA Kit for A Disintegrin And Metalloprotease 22 (ADAM22) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant A Disintegrin And Metalloprotease 22 (ADAM22) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to A Disintegrin And Metalloprotease 22 (ADAM22) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to A Disintegrin And Metalloprotease 22 (ADAM22) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for A Disintegrin And Metalloprotease 22 (ADAM22) CLIA Kit Customized Service Offer
n/a ELISA Kit for A Disintegrin And Metalloprotease 22 (ADAM22) ELISA Kit Customized Service Offer
  1. "Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain."Biochem. J. 334:93-98(1998) [PubMed] [Europe PMC] [Abstract]
  2. "The specific expression of three novel splice variant forms of human metalloprotease-like disintegrin-like cysteine-rich protein 2 gene in brain tissues and gliomas."Jpn. J. Cancer Res. 91:1001-1006(2000) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The identification of seven metalloproteinase-disintegrin (ADAM) genes from genomic libraries."Gene 237:61-70(1999) [PubMed] [Europe PMC] [Abstract]
  5. "The interaction between ADAM 22 and 14-3-3zeta: regulation of cell adhesion and spreading."Biochem. Biophys. Res. Commun. 301:991-999(2003) [PubMed] [Europe PMC] [Abstract]
  6. "An unappreciated role for RNA surveillance."Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
  7. "ADAM22 plays an important role in cell adhesion and spreading with the assistance of 14-3-3."Biochem. Biophys. Res. Commun. 331:938-946(2005) [PubMed] [Europe PMC] [Abstract]
  8. "ADAM22, expressed in normal brain but not in high-grade gliomas, inhibits cellular proliferation via the disintegrin domain."Neurosurgery 58:179-186(2006) [PubMed] [Europe PMC] [Abstract]
  9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Structural characterization of the ectodomain of a disintegrin and metalloproteinase-22 (ADAM22), a neural adhesion receptor instead of metalloproteinase: insights on ADAM function."J. Biol. Chem. 284:29077-29086(2009) [PubMed] [Europe PMC] [Abstract]