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RNA Polymerase II, DNA Directed Polypeptide E (POLR2E)

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RPABC1; RPB5; XAP4; hRPB25; hsRPB5; DNA-directed RNA polymerase II 23 kDa polypeptide; DNA-directed RNA polymerases I, II, and III subunit RPABC1

RNA Polymerase II, DNA Directed Polypeptide E (POLR2E)
CCC K149
HGNC 9192
MGI 1913670
PubMed 19787249
RGD 1589817
UniProt P19388
Wiki POLR2E
POLR2E encodes the fifth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases and is present in two-fold molar excess over the other polymerase subunits. An interaction between this subunit and a hepatitis virus transactivating protein has been demonstrated, suggesting that interaction between transcriptional activators and the polymerase can occur through this subunit. A pseudogene is located on chromosome 11.
A second site of hybridization to 11q23.1 was thought to represent a pseudogene, most likely a retroposon, since no remnants of introns could be identified in the study of genomic DNA.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RNA Polymerase II, DNA Directed Polypeptide E (POLR2E) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RNA Polymerase II, DNA Directed Polypeptide E (POLR2E) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RNA Polymerase II, DNA Directed Polypeptide E (POLR2E) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RNA Polymerase II, DNA Directed Polypeptide E (POLR2E) CLIA Kit Customized Service Offer
n/a ELISA Kit for RNA Polymerase II, DNA Directed Polypeptide E (POLR2E) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RNA Polymerase II, DNA Directed Polypeptide E (POLR2E) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RNA Polymerase II, DNA Directed Polypeptide E (POLR2E) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RNA Polymerase II, DNA Directed Polypeptide E (POLR2E) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RNA Polymerase II, DNA Directed Polypeptide E (POLR2E) CLIA Kit Customized Service Offer
n/a ELISA Kit for RNA Polymerase II, DNA Directed Polypeptide E (POLR2E) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RNA Polymerase II, DNA Directed Polypeptide E (POLR2E) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RNA Polymerase II, DNA Directed Polypeptide E (POLR2E) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RNA Polymerase II, DNA Directed Polypeptide E (POLR2E) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RNA Polymerase II, DNA Directed Polypeptide E (POLR2E) CLIA Kit Customized Service Offer
n/a ELISA Kit for RNA Polymerase II, DNA Directed Polypeptide E (POLR2E) ELISA Kit Customized Service Offer
  1. "Isolation and molecular characterization of a cDNA encoding the 23-kDa subunit of human RNA polymerase II."J. Biol. Chem. 264:13114-13121(1989) [PubMed] [Europe PMC] [Abstract]
  2. ErratumJ. Biol. Chem. 266:13468-13468(1991) [PubMed] [Europe PMC] [Abstract]
  3. "Human RPB5, a subunit shared by eukaryotic nuclear RNA polymerases, binds human hepatitis B virus X protein and may play a role in X transactivation."EMBO J. 14:143-150(1995) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes."J. Biol. Chem. 273:34444-34453(1998) [PubMed] [Europe PMC] [Abstract]
  8. "RMP, a novel RNA polymerase II subunit 5-interacting protein, counteracts transactivation by hepatitis B virus X protein."Mol. Cell. Biol. 18:7546-7555(1998) [PubMed] [Europe PMC] [Abstract]
  9. "RNA polymerase I-specific subunit CAST/hPAF49 has a role in the activation of transcription by upstream binding factor."Mol. Cell. Biol. 26:5436-5448(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]