DnaJ/HSP40 Homolog Subfamily C, Member 7 (DNAJC7)

DNAJC7 encodes a member of the DNAJ heat shock protein 40 family of proteins that is characterized by two N-terminal tetratricopeptide repeat domains and a C-terminal DNAJ domain. This protein binds the chaperone proteins heat shock proteins 70 and 90 in an ATP-dependent manner and may function as a co-chaperone. Pseudogenes of this gene are found on chromosomes 1 and 6. Alternate splicing results in multiple transcript variants.The predicted type III transmembrane protein contains 494 amino acids, with a J domain from residues 379 to 448. Mouse and human DNAJC7 share 96% amino acid identity. The predicted product of one is TPR2, which is homologous to the human tetratricopeptide repeat protein-2. That of the second is HDJ1, homologous to human HDJ1 (DNAJB1).