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Anti-Silencing Function 1 Homolog A (ASF1A)

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CGI-98; CIA; HSPC146; CCG1-interacting factor A; Histone chaperone ASF1A

Anti-Silencing Function 1 Homolog A (ASF1A)
CCC K122
HGNC 20995
MGI 1913653
PubMed 21727091
RGD 1311941
UniProt Q9Y294
Wiki ASF1A
ASF1A encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The protein is a key component of a histone donor complex that functions in nucleosome assembly. It interacts with histones H3 and H4, and functions together with a chromatin assembly factor during DNA replication and repair. The deduced protein contains 204 amino acids. The N-terminal 153 amino acids share 59% identity with yeast Asf1, but the C terminus shows little homology.The deduced 205-amino acid ASF1A protein has a calculated molecular mass of 22.9 kD and shares 71% amino acid identity with ASF1B.ASF1A was rapidly dephosphorylated upon inhibition of DNA replication and activation of the DNA replication checkpoint, concomitant with inactivation of TLKs.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Anti-Silencing Function 1 Homolog A (ASF1A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Anti-Silencing Function 1 Homolog A (ASF1A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Anti-Silencing Function 1 Homolog A (ASF1A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Anti-Silencing Function 1 Homolog A (ASF1A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Anti-Silencing Function 1 Homolog A (ASF1A) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Anti-Silencing Function 1 Homolog A (ASF1A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Anti-Silencing Function 1 Homolog A (ASF1A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Anti-Silencing Function 1 Homolog A (ASF1A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Anti-Silencing Function 1 Homolog A (ASF1A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Anti-Silencing Function 1 Homolog A (ASF1A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Anti-Silencing Function 1 Homolog A (ASF1A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Anti-Silencing Function 1 Homolog A (ASF1A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Anti-Silencing Function 1 Homolog A (ASF1A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Anti-Silencing Function 1 Homolog A (ASF1A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Anti-Silencing Function 1 Homolog A (ASF1A) ELISA Kit Customized Service Offer
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  2. "Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases."Curr. Biol. 11:1068-1073(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
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  5. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway."EMBO Rep. 3:329-334(2002) [PubMed] [Europe PMC] [Abstract]
  10. "Identification and characterization of CIA/ASF1 as an interactor of bromodomains associated with TFIID."Proc. Natl. Acad. Sci. U.S.A. 99:9334-9339(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Structure and function of the conserved core of histone deposition protein Asf1."Curr. Biol. 13:2148-2158(2003) [PubMed] [Europe PMC] [Abstract]
  12. "Transcription initiation factor IID-interactive histone chaperone CIA-II implicated in mammalian spermatogenesis."J. Biol. Chem. 278:35660-35667(2003) [PubMed] [Europe PMC] [Abstract]
  13. "Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis."Cell 116:51-61(2004) [PubMed] [Europe PMC] [Abstract]
  14. "Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA."Dev. Cell 8:19-30(2005) [PubMed] [Europe PMC] [Abstract]
  15. "Functional conservation and specialization among eukaryotic anti-silencing function 1 histone chaperones."Eukaryot. Cell 4:1583-1590(2005) [PubMed] [Europe PMC] [Abstract]
  16. "Human Asf1 regulates the flow of S phase histones during replicational stress."Mol. Cell 17:301-311(2005) [PubMed] [Europe PMC] [Abstract]
  17. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  18. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells."Mol. Cell. Biol. 29:758-770(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Phosphorylation-mediated control of histone chaperone ASF1 levels by Tousled-like kinases."PLoS ONE 4:E8328-E8328(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  22. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  23. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  24. "Codanin-1, mutated in the anaemic disease CDAI, regulates Asf1 function in S-phase histone supply."EMBO J. 31:2013-2023(2012) [PubMed] [Europe PMC] [Abstract]
  25. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  26. "Binding of the histone chaperone ASF1 to the CBP bromodomain promotes histone acetylation."Proc. Natl. Acad. Sci. U.S.A. 111:E1072-E1081(2014) [PubMed] [Europe PMC] [Abstract]
  27. "Structural basis for the interaction of Asf1 with histone H3 and its functional implications."Proc. Natl. Acad. Sci. U.S.A. 102:5975-5980(2005) [PubMed] [Europe PMC] [Abstract]
  28. "Structure of a human ASF1a-HIRA complex and insights into specificity of histone chaperone complex assembly."Nat. Struct. Mol. Biol. 13:921-929(2006) [PubMed] [Europe PMC] [Abstract]