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Anti-Silencing Function 1 Homolog B (ASF1B)

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CIA-II; CCG1-interacting factor A-II; Histone chaperone ASF1B

Anti-Silencing Function 1 Homolog B (ASF1B)
CCC K121
HGNC 20996
MGI 1914179
PubMed 23645555
RGD 1304918
UniProt Q9NVP2
Wiki ASF1B
ASF1B encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The encoded protein is the substrate of the tousled-like kinase family of cell cycle-regulated kinases, and may play a key role in modulating the nucleosome structure of chromatin by ensuring a constant supply of histones at sites of nucleosome assembly.
The deduced 203-amino acid ASF1B protein has a calculated molecular mass of 22.4 kD. ASF1B and ASF1A share 71% amino acid identity, and they share about 50% identity with yeast Asf1, which has a C-terminal acidic stretch not found in the human ASF1 proteins.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Anti-Silencing Function 1 Homolog B (ASF1B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Anti-Silencing Function 1 Homolog B (ASF1B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Anti-Silencing Function 1 Homolog B (ASF1B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Anti-Silencing Function 1 Homolog B (ASF1B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Anti-Silencing Function 1 Homolog B (ASF1B) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Anti-Silencing Function 1 Homolog B (ASF1B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Anti-Silencing Function 1 Homolog B (ASF1B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Anti-Silencing Function 1 Homolog B (ASF1B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Anti-Silencing Function 1 Homolog B (ASF1B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Anti-Silencing Function 1 Homolog B (ASF1B) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Anti-Silencing Function 1 Homolog B (ASF1B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Anti-Silencing Function 1 Homolog B (ASF1B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Anti-Silencing Function 1 Homolog B (ASF1B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Anti-Silencing Function 1 Homolog B (ASF1B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Anti-Silencing Function 1 Homolog B (ASF1B) ELISA Kit Customized Service Offer
  1. "Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases."Curr. Biol. 11:1068-1073(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Transcription initiation factor IID-interactive histone chaperone CIA-II implicated in mammalian spermatogenesis."J. Biol. Chem. 278:35660-35667(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway."EMBO Rep. 3:329-334(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis."Cell 116:51-61(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Functional conservation and specialization among eukaryotic anti-silencing function 1 histone chaperones."Eukaryot. Cell 4:1583-1590(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Human Asf1 regulates the flow of S phase histones during replicational stress."Mol. Cell 17:301-311(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Asf1 is required for viability and chromatin assembly during DNA replication in vertebrate cells."J. Biol. Chem. 281:13817-13827(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Structure of a human ASF1a-HIRA complex and insights into specificity of histone chaperone complex assembly."Nat. Struct. Mol. Biol. 13:921-929(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Phosphorylation-mediated control of histone chaperone ASF1 levels by Tousled-like kinases."PLoS ONE 4:E8328-E8328(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Codanin-1, mutated in the anaemic disease CDAI, regulates Asf1 function in S-phase histone supply."EMBO J. 31:2013-2023(2012) [PubMed] [Europe PMC] [Abstract]
  16. "Binding of the histone chaperone ASF1 to the CBP bromodomain promotes histone acetylation."Proc. Natl. Acad. Sci. U.S.A. 111:E1072-E1081(2014) [PubMed] [Europe PMC] [Abstract]