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Small Nuclear Ribonucleoprotein 40kDa (SNRNP40)

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WDR57; 40K; PRP8BP; PRPF8BP; SPF38; WD Repeat Domain 57(U5 snRNP Specific); 38 kDa-splicing factor; Prp8-binding protein; U5 snRNP-specific 40 kDa protein

Small Nuclear Ribonucleoprotein 40kDa (SNRNP40)
CCC K120
HGNC 30857
MGI 1913835
PubMed 9774689
RGD 1309198
UniProt Q96DI7
Wiki WDR57
SPF38 is a component of the U5 small nuclear ribonucleoprotein (snRNP) particle. The U5 snRNP is part of the spliceosome, a multiprotein complex involved in the removal of introns from nuclear pre-mRNAs.The deduced 357-amino acid protein has a calculated molecular mass of 39.3 kD. Except for 63 N-terminal amino acids, the entire SPF38 protein is made up of 7 WD40 repeats. Highly homologous protein sequences were found in rat, mouse, fruit fly, and plant EST databases.SPF38 has a calculated molecular mass of 38.4 kD and shows an apparent molecular mass of 30 kD in 2-dimensional gels.By sedimentation analysis, radioimmunoprecipitations, and Far Western (overlay) analysis, Achsel et al. (1998) determined that SPF38 interacts directly with PRPF8.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Small Nuclear Ribonucleoprotein 40kDa (SNRNP40) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Small Nuclear Ribonucleoprotein 40kDa (SNRNP40) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Small Nuclear Ribonucleoprotein 40kDa (SNRNP40) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Small Nuclear Ribonucleoprotein 40kDa (SNRNP40) CLIA Kit Customized Service Offer
n/a ELISA Kit for Small Nuclear Ribonucleoprotein 40kDa (SNRNP40) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Small Nuclear Ribonucleoprotein 40kDa (SNRNP40) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Small Nuclear Ribonucleoprotein 40kDa (SNRNP40) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Small Nuclear Ribonucleoprotein 40kDa (SNRNP40) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Small Nuclear Ribonucleoprotein 40kDa (SNRNP40) CLIA Kit Customized Service Offer
n/a ELISA Kit for Small Nuclear Ribonucleoprotein 40kDa (SNRNP40) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Small Nuclear Ribonucleoprotein 40kDa (SNRNP40) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Small Nuclear Ribonucleoprotein 40kDa (SNRNP40) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Small Nuclear Ribonucleoprotein 40kDa (SNRNP40) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Small Nuclear Ribonucleoprotein 40kDa (SNRNP40) CLIA Kit Customized Service Offer
n/a ELISA Kit for Small Nuclear Ribonucleoprotein 40kDa (SNRNP40) ELISA Kit Customized Service Offer
  1. "The human U5-220kD protein (hPrp8) forms a stable RNA-free complex with several U5-specific proteins, including an RNA unwindase, a homologue of ribosomal elongation factor EF-2, and a novel WD-40 protein."Mol. Cell. Biol. 18:6756-6766(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex."Nat. Genet. 20:46-50(1998) [PubMed] [Europe PMC] [Abstract]
  6. "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis."RNA 8:426-439(2002) [PubMed] [Europe PMC] [Abstract]
  7. "The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP."RNA 12:1418-1430(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]