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DNA Cross Link Repair 1C Protein (DCLRE1C)

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A-SCID; DCLREC1C; RS-SCID; SCIDA; ARTEMIS; SNM1C; SNM1C; Severe Combined Immunodeficiency,Type A(Athabascan)

DNA Cross Link Repair 1C Protein (DCLRE1C)
CCC K114
HGNC 17642
MGI 2441769
PubMed 21184155
RGD 708574
UniProt Q96SD1
Wiki DCLRE1C
DCLRE1C encodes a nuclear protein that is involved in V(D)J recombination and DNA repair. The protein has single-strand-specific 5'-3' exonuclease activity; it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins when complexed with protein kinase, DNA-activated, catalytic polypeptide.The purified Artemis protein alone possesses single-strand-specific 5-prime-to-3-prime exonuclease activity. Upon complex formation, PRKDC phosphorylates Artemis, and Artemis acquires endonucleolytic activity on 5-prime and 3-prime overhangs, as well as hairpins. PRKDC regulates Artemis by both phosphorylation and complex formation to permit enzymatic activities that are critical for the hairpin-opening step of V(D)J recombination and for the 5-prime and 3-prime overhang processing in nonhomologous DNA end joining.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DNA Cross Link Repair 1C Protein (DCLRE1C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DNA Cross Link Repair 1C Protein (DCLRE1C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DNA Cross Link Repair 1C Protein (DCLRE1C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DNA Cross Link Repair 1C Protein (DCLRE1C) CLIA Kit Customized Service Offer
n/a ELISA Kit for DNA Cross Link Repair 1C Protein (DCLRE1C) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DNA Cross Link Repair 1C Protein (DCLRE1C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DNA Cross Link Repair 1C Protein (DCLRE1C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DNA Cross Link Repair 1C Protein (DCLRE1C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DNA Cross Link Repair 1C Protein (DCLRE1C) CLIA Kit Customized Service Offer
n/a ELISA Kit for DNA Cross Link Repair 1C Protein (DCLRE1C) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DNA Cross Link Repair 1C Protein (DCLRE1C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DNA Cross Link Repair 1C Protein (DCLRE1C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DNA Cross Link Repair 1C Protein (DCLRE1C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DNA Cross Link Repair 1C Protein (DCLRE1C) CLIA Kit Customized Service Offer
n/a ELISA Kit for DNA Cross Link Repair 1C Protein (DCLRE1C) ELISA Kit Customized Service Offer
  1. "Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency."Cell 105:177-186(2001) [PubMed] [Europe PMC] [Abstract]
  2. "A founder mutation in Artemis, an SNM1-like protein, causes SCID in Athabascan-speaking native Americans."J. Immunol. 168:6323-6329(2002) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination."Cell 108:781-794(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Metallo-beta-lactamase fold within nucleic acids processing enzymes: the beta-CASP family."Nucleic Acids Res. 30:3592-3601(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Functional and biochemical dissection of the structure-specific nuclease ARTEMIS."EMBO J. 23:1987-1997(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Phosphorylation of Artemis following irradiation-induced DNA damage."Eur. J. Immunol. 34:3146-3155(2004) [PubMed] [Europe PMC] [Abstract]
  10. "The metallo-beta-lactamase/beta-CASP domain of Artemis constitutes the catalytic core for V(D)J recombination."J. Exp. Med. 199:315-321(2004) [PubMed] [Europe PMC] [Abstract]
  11. "A biochemically defined system for mammalian nonhomologous DNA end joining."Mol. Cell 16:701-713(2004) [PubMed] [Europe PMC] [Abstract]
  12. "A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci."Mol. Cell 16:715-724(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response."Mol. Cell. Biol. 24:9207-9220(2004) [PubMed] [Europe PMC] [Abstract]
  14. "Ataxia-telangiectasia-mutated dependent phosphorylation of Artemis in response to DNA damage."Cancer Sci. 96:134-141(2005) [PubMed] [Europe PMC] [Abstract]
  15. "Artemis deficiency confers a DNA double-strand break repair defect and Artemis phosphorylation status is altered by DNA damage and cell cycle progression."DNA Repair 4:556-570(2005) [PubMed] [Europe PMC] [Abstract]
  16. "The Artemis:DNA-PKcs endonuclease cleaves DNA loops, flaps, and gaps."DNA Repair 4:845-851(2005) [PubMed] [Europe PMC] [Abstract]
  17. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Radiosensitive SCID patients with Artemis gene mutations show a complete B-cell differentiation arrest at the pre-B-cell receptor checkpoint in bone marrow."Blood 101:1446-1452(2003) [PubMed] [Europe PMC] [Abstract]
  19. "Expansion of clonotype-restricted HLA-identical maternal CD4+ T cells in a patient with severe combined immunodeficiency and a homozygous mutation in the Artemis gene."Clin. Immunol. 108:159-166(2003) [PubMed] [Europe PMC] [Abstract]
  20. "Novel Artemis gene mutations of radiosensitive severe combined immunodeficiency in Japanese families."Hum. Genet. 112:348-352(2003) [PubMed] [Europe PMC] [Abstract]
  21. "Partial T and B lymphocyte immunodeficiency and predisposition to lymphoma in patients with hypomorphic mutations in Artemis."J. Clin. Invest. 111:381-387(2003) [PubMed] [Europe PMC] [Abstract]
  22. "Omenn syndrome due to ARTEMIS mutations."Blood 105:4179-4186(2005) [PubMed] [Europe PMC] [Abstract]