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RAD50 Interacting Protein 1 (RINT1)

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HsRINT-1; RAD50 interactor 1

RAD50 Interacting Protein 1 (RINT1)
CCC K112
HGNC 21876
MGI 1916233
PubMed 23074196
UniProt Q6NUQ1
Wiki RINT1
The deduced 792-amino acid protein has several leucine heptad repeats that form an N-terminal coiled-coil region. Western blot analysis of human cell lines detected an 87-kD RINT1 doublet. Further experiments suggested that the higher molecular mass protein may be translated from an upstream non-AUG start codon.
RINT1 bound RAD50 only during late S and G2/M phases, and human breast cancer cells expressing an N-terminally truncated RINT1 protein displayed defective radiation-induced G2/M checkpoint. the second leucine heptad repeat of RAD50 and amino acids 257 to 792 of RINT1 were required for RAD50-RINT1 interaction. RINT1 may play a role in cell cycle control after DNA damage.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAD50 Interacting Protein 1 (RINT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAD50 Interacting Protein 1 (RINT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAD50 Interacting Protein 1 (RINT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAD50 Interacting Protein 1 (RINT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAD50 Interacting Protein 1 (RINT1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAD50 Interacting Protein 1 (RINT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAD50 Interacting Protein 1 (RINT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAD50 Interacting Protein 1 (RINT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAD50 Interacting Protein 1 (RINT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAD50 Interacting Protein 1 (RINT1) ELISA Kit Customized Service Offer
  1. "RINT-1, a novel Rad50-interacting protein, participates in radiation-induced G2/M checkpoint control."J. Biol. Chem. 276:6105-6111(2001) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi."EMBO J. 23:1267-1278(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion."EMBO J. 23:3216-3226(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The Rb-related p130 protein controls telomere lengthening through an interaction with a Rad50-interacting protein, RINT-1."Mol. Cell 22:63-71(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]