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Bromodomain Adjacent To Zinc Finger Domain Protein 1B (BAZ1B)

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WBSCR10; WBSCR9; WSTF; hWALp2; Williams-Beuren Syndrome Chromosome Region 9; Williams syndrome transcription factor; Tyrosine-protein kinase BAZ1B

Bromodomain Adjacent To Zinc Finger Domain Protein 1B (BAZ1B)
CCC K096
HGNC 961
MGI 1353499
PubMed 23756441
RGD 1597089
UniProt Q9UIG0
Wiki BAZ1B
BAZ1B encodes a member of the bromodomain protein family. The bromodomain is a structural motif characteristic of proteins involved in chromatin-dependent regulation of transcription. This gene is deleted in Williams-Beuren syndrome, a developmental disorder caused by deletion of multiple genes at 7q11.23. The WSTF cDNA encodes a 1,425-amino acid protein that contains a PHD finger followed by a bromodomain. The protein shows 40 to 50% overall sequence identity with several transcription factors, including GCN5 and CBP. It also has multiple phosphorylation, N-myristylation, amidation, and potential glycosylation sites. Northern blot analysis detected ubiquitous expression of a 7.5-kb transcript; in adult issues, highest expression was found in heart, brain, placenta, skeletal muscle, and ovary.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Bromodomain Adjacent To Zinc Finger Domain Protein 1B (BAZ1B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Bromodomain Adjacent To Zinc Finger Domain Protein 1B (BAZ1B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Bromodomain Adjacent To Zinc Finger Domain Protein 1B (BAZ1B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Bromodomain Adjacent To Zinc Finger Domain Protein 1B (BAZ1B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Bromodomain Adjacent To Zinc Finger Domain Protein 1B (BAZ1B) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Bromodomain Adjacent To Zinc Finger Domain Protein 1B (BAZ1B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Bromodomain Adjacent To Zinc Finger Domain Protein 1B (BAZ1B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Bromodomain Adjacent To Zinc Finger Domain Protein 1B (BAZ1B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Bromodomain Adjacent To Zinc Finger Domain Protein 1B (BAZ1B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Bromodomain Adjacent To Zinc Finger Domain Protein 1B (BAZ1B) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Bromodomain Adjacent To Zinc Finger Domain Protein 1B (BAZ1B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Bromodomain Adjacent To Zinc Finger Domain Protein 1B (BAZ1B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Bromodomain Adjacent To Zinc Finger Domain Protein 1B (BAZ1B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Bromodomain Adjacent To Zinc Finger Domain Protein 1B (BAZ1B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Bromodomain Adjacent To Zinc Finger Domain Protein 1B (BAZ1B) ELISA Kit Customized Service Offer
  1. "Identification of the WBSCR9 gene, encoding a novel transcriptional regulator, in the Williams-Beuren syndrome deletion at 7q11.23."Cytogenet. Cell Genet. 82:238-246(1998) [PubMed] [Europe PMC] [Abstract]
  2. "A novel human gene, WSTF, is deleted in Williams Syndrome."Genomics 54:241-249(1998) [PubMed] [Europe PMC] [Abstract]
  3. "A novel family of bromodomain genes."Genomics 63:40-45(2000) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "WSTF-ISWI chromatin remodeling complex targets heterochromatic replication foci."EMBO J. 21:2231-2241(2002) [PubMed] [Europe PMC] [Abstract]
  7. "The Williams syndrome transcription factor interacts with PCNA to target chromatin remodelling by ISWI to replication foci."Nat. Cell Biol. 6:1236-1244(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Ligand-induced transrepression by VDR through association of WSTF with acetylated histones."EMBO J. 24:3881-3894(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  10. "The WSTF-SNF2h chromatin remodeling complex interacts with several nuclear proteins in transcription."J. Biol. Chem. 281:16264-16271(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Identification of novel human Cdt1-binding proteins by a proteomics approach: proteolytic regulation by APC/CCdh1."Mol. Biol. Cell 19:1007-1021(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  13. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  15. "WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity."Nature 457:57-62(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions."Nature 458:591-596(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  19. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  20. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  21. "Structure of the PHD zinc finger from human Williams-Beuren syndrome transcription factor."J. Mol. Biol. 304:723-729(2000) [PubMed] [Europe PMC] [Abstract]