≡

AarF Domain Containing Kinase 3 (ADCK3)

[Edit]

CABC1; COQ8; Chaperone,ABC1 Activity Of BC1 Complex Like; Coenzyme Q8 Homolog; Atypical kinase ADCK3, mitochondrial; Chaperone activity of bc1 complex-like

AarF Domain Containing Kinase 3 (ADCK3)
CCC K092
HGNC 16812
MGI 1914676
PubMed 18319074
RGD 1308245
UniProt Q8NI60
Wiki ADCK3
CABC1 encodes a mitochondrial protein similar to yeast ABC1, which functions in an electron-transferring membrane protein complex in the respiratory chain. It is not related to the family of ABC transporter proteins. Expression of this gene is induced by the tumor suppressor p53 and in response to DNA damage, and inhibiting its expression partially suppresses p53-induced apoptosis.
The protein shares 47% and 46% sequence identity with the ABC1 proteins of Arabidopsis thaliana and S. pombe, respectively. Northern blot analysis revealed ubiquitous expression of a 3.2-kb transcript, with relatively greater abundance in heart and skeletal muscle.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant AarF Domain Containing Kinase 3 (ADCK3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to AarF Domain Containing Kinase 3 (ADCK3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to AarF Domain Containing Kinase 3 (ADCK3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for AarF Domain Containing Kinase 3 (ADCK3) CLIA Kit Customized Service Offer
n/a ELISA Kit for AarF Domain Containing Kinase 3 (ADCK3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant AarF Domain Containing Kinase 3 (ADCK3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to AarF Domain Containing Kinase 3 (ADCK3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to AarF Domain Containing Kinase 3 (ADCK3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for AarF Domain Containing Kinase 3 (ADCK3) CLIA Kit Customized Service Offer
n/a ELISA Kit for AarF Domain Containing Kinase 3 (ADCK3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant AarF Domain Containing Kinase 3 (ADCK3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to AarF Domain Containing Kinase 3 (ADCK3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to AarF Domain Containing Kinase 3 (ADCK3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for AarF Domain Containing Kinase 3 (ADCK3) CLIA Kit Customized Service Offer
n/a ELISA Kit for AarF Domain Containing Kinase 3 (ADCK3) ELISA Kit Customized Service Offer
  1. "Isolation of a novel gene, CABC1, encoding a mitochondrial protein that is highly homologous to yeast activity of bc1 complex."Cancer Res. 62:1246-1250(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Large-scale cDNA transfection screening for genes related to cancer development and progression." Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Mitochondrial ADCK3 employs an atypical protein kinase-like fold to enable coenzyme Q biosynthesis."Mol. Cell 57:83-94(2015) [PubMed] [Europe PMC] [Abstract]
  8. "Nonsense mutations in CABC1/ADCK3 cause progressive cerebellar ataxia and atrophy."Mitochondrion 10:510-515(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Expression of the human atypical kinase ADCK3 rescues coenzyme Q biosynthesis and phosphorylation of Coq polypeptides in yeast coq8 mutants."Biochim. Biophys. Acta 1811:348-360(2011) [PubMed] [Europe PMC] [Abstract]
  11. "ADCK4 mutations promote steroid-resistant nephrotic syndrome through CoQ10 biosynthesis disruption." J. Clin. Invest. 123:5179-5189(2013) [PubMed] [Europe PMC] [Abstract]
  12. "A Gly-zipper motif mediates homodimerization of the transmembrane domain of the mitochondrial kinase ADCK3."J. Am. Chem. Soc. 136:14068-14077(2014) [PubMed] [Europe PMC] [Abstract]
  13. "Autosomal-recessive cerebellar ataxia caused by a novel ADCK3 mutation that elongates the protein: clinical, genetic and biochemical characterisation."J. Neurol. Neurosurg. Psych. 85:493-498(2014) [PubMed] [Europe PMC] [Abstract]
  14. "Preparation and characterization of human ADCK3, a putative atypical kinase."Protein Expr. Purif. 108:13-17(2015) [PubMed] [Europe PMC] [Abstract]
  15. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
  16. "CABC1 gene mutations cause ubiquinone deficiency with cerebellar ataxia and seizures."Am. J. Hum. Genet. 82:623-630(2008) [PubMed] [Europe PMC] [Abstract]
  17. "ADCK3, an ancestral kinase, is mutated in a form of recessive ataxia associated with coenzyme Q10 deficiency." Am. J. Hum. Genet. 82:661-672(2008) [PubMed] [Europe PMC] [Abstract]
  18. "Adult-onset cerebellar ataxia due to mutations in CABC1/ADCK3."J. Neurol. Neurosurg. Psych. 83:174-178(2012) [PubMed] [Europe PMC] [Abstract]
  19. "Heterozygous mutations in the ADCK3 gene in siblings with cerebellar atrophy and extreme phenotypic variability."JIMD Rep. 12:103-107(2014) [PubMed] [Europe PMC] [Abstract]