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SH2B Adaptor Protein 1 (SH2B1)

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SH2-B; SH2B; PSM; SH2 domain-containing protein 1B; Pro-rich, PH and SH2 domain-containing signaling mediator

SH2B Adaptor Protein 1 (SH2B1)
CCC K087
HGNC 30417
MGI 1201407
PubMed 17565041
UniProt Q9NRF2
Wiki SH2B1
SH2B1 encodes a member of the SH2-domain containing mediators family. The encoded protein mediates activation of various kinases and may function in cytokine and growth factor receptor signaling and cellular transformation. Alternatively spliced transcript variants have been described.
The deduced 670-amino acid protein contains an SH2 domain in its C-terminal half. The rat Sh2b-alpha protein contains 757 amino acids and is identical to Sh2b-beta through the SH2 domain, but the proteins have different C termini.The deduced 682-amino acid protein differs from Sh2b-alpha and Sh2b-beta only in the C terminus. Northern blot analysis detected expression in all mouse tissues examined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SH2B Adaptor Protein 1 (SH2B1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SH2B Adaptor Protein 1 (SH2B1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SH2B Adaptor Protein 1 (SH2B1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SH2B Adaptor Protein 1 (SH2B1) CLIA Kit Customized Service Offer
n/a ELISA Kit for SH2B Adaptor Protein 1 (SH2B1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SH2B Adaptor Protein 1 (SH2B1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SH2B Adaptor Protein 1 (SH2B1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SH2B Adaptor Protein 1 (SH2B1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SH2B Adaptor Protein 1 (SH2B1) CLIA Kit Customized Service Offer
n/a ELISA Kit for SH2B Adaptor Protein 1 (SH2B1) ELISA Kit Customized Service Offer
  1. "Kinase activation through dimerization by human SH2-B."Mol. Cell. Biol. 25:2607-2621(2005) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "PSM, an insulin-dependent, pro-rich, PH, SH2 domain containing partner of the insulin receptor."J. Biochem. 122:1105-1113(1997) [PubMed] [Europe PMC] [Abstract]
  8. "SH2-Balpha is an insulin-receptor adapter protein and substrate that interacts with the activation loop of the insulin-receptor kinase."Biochem. J. 335:103-109(1998) [PubMed] [Europe PMC] [Abstract]
  9. "Platelet-derived growth factor (PDGF) stimulates the association of SH2-Bbeta with PDGF receptor and phosphorylation of SH2-Bbeta."J. Biol. Chem. 273:21239-21245(1998) [PubMed] [Europe PMC] [Abstract]
  10. "Alternative splicing, gene localization, and binding of SH2-B to the insulin receptor kinase domain."Mamm. Genome 10:1160-1167(1999) [PubMed] [Europe PMC] [Abstract]
  11. "SH2-B family members differentially regulate JAK family tyrosine kinases."J. Biol. Chem. 277:8673-8681(2002) [PubMed] [Europe PMC] [Abstract]
  12. "Interaction of fibroblast growth factor receptor 3 and the adapter protein SH2-B. A role in STAT5 activation."J. Biol. Chem. 277:15962-15970(2002) [PubMed] [Europe PMC] [Abstract]
  13. "SH2-B is a positive regulator of nerve growth factor-mediated activation of the Akt/Forkhead pathway in PC12 cells."J. Biol. Chem. 279:133-141(2004) [PubMed] [Europe PMC] [Abstract]
  14. "Interaction of SH2-Bbeta with RET is involved in signaling of GDNF-induced neurite outgrowth."J. Cell Sci. 119:1666-1676(2006) [PubMed] [Europe PMC] [Abstract]
  15. "SH2B1beta adaptor is a key enhancer of RET tyrosine kinase signaling."Oncogene 26:6546-6559(2007) [PubMed] [Europe PMC] [Abstract]
  16. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  17. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]