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Unc-51 Like Kinase 1 (ULK1)

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ATG1; UNC51; Unc51.1; ATG1 Autophagy Related 1 Homolog; Serine/threonine-protein kinase ULK1

Unc-51 Like Kinase 1 (ULK1)
CCC K079
HGNC 12558
MGI 1270126
PubMed 23685627
RGD 1589743
UniProt O75385
Wiki ULK1
The C. elegans unc51 gene encodes a serine/threonine kinase expressed almost exclusively in neurons. Mutations in unc51 result in abnormal axonal extension and growth, leading to a paralyzed, egg laying-defective, and dumpy phenotype. Unc51.1 inhibited SynGAP through its kinase activity.
Using the rat fragment as a probe for screening human fetal brain and neuroblastoma NT-2 cDNA libraries, the authors cloned UNC51-like kinase-1 (ULK1) cDNAs. The predicted 1,050-amino acid human protein shares 29% sequence identity with nematode unc51. Northern blot analysis revealed that ULK1 was expressed as a 6-kb mRNA in all human adult tissues examined, with the highest levels in skeletal muscle and heart.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Unc-51 Like Kinase 1 (ULK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Unc-51 Like Kinase 1 (ULK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Unc-51 Like Kinase 1 (ULK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Unc-51 Like Kinase 1 (ULK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Unc-51 Like Kinase 1 (ULK1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Unc-51 Like Kinase 1 (ULK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Unc-51 Like Kinase 1 (ULK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Unc-51 Like Kinase 1 (ULK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Unc-51 Like Kinase 1 (ULK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Unc-51 Like Kinase 1 (ULK1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Unc-51 Like Kinase 1 (ULK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Unc-51 Like Kinase 1 (ULK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Unc-51 Like Kinase 1 (ULK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Unc-51 Like Kinase 1 (ULK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Unc-51 Like Kinase 1 (ULK1) ELISA Kit Customized Service Offer
  1. "Human ULK1, a novel serine/threonine kinase related to UNC-51 kinase of Caenorhabditis elegans: cDNA cloning, expression, and chromosomal assignment."Genomics 51:76-85(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  4. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation."Brain Res. Mol. Brain Res. 85:1-12(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  9. "A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy."Autophagy 5:649-662(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Atg101, a novel mammalian autophagy protein interacting with Atg13."Autophagy 5:973-979(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy."Mol. Biol. Cell 20:1981-1991(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism."Mol. Cell. Biol. 29:157-171(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop."Autophagy 7:696-706(2011) [PubMed] [Europe PMC] [Abstract]
  17. "ULK1 inhibits the kinase activity of mTORC1 and cell proliferation."Autophagy 7:1212-1221(2011) [PubMed] [Europe PMC] [Abstract]
  18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  19. "Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy."Science 331:456-461(2011) [PubMed] [Europe PMC] [Abstract]
  20. "Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC."EMBO J. 31:1931-1946(2012) [PubMed] [Europe PMC] [Abstract]
  21. "TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomes."J. Cell Biol. 197:659-675(2012) [PubMed] [Europe PMC] [Abstract]
  22. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]