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Enhancer Of Zeste Homolog 2 (EZH2)

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ENX-1; KMT6; KMT6A; Histone-lysine N-methyltransferase EZH2; Lysine N-methyltransferase 6

Enhancer Of Zeste Homolog 2 (EZH2)
CCC K073
HGNC 3527
MGI 107940
PubMed 24867641
RGD 1595860
UniProt Q15910
Wiki EZH2
EZH2 encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. EZH2 acts mainly as a gene silencer; it performs this role by the addition of three methyl groups to Lysine 27 of histone 3, a modification leading to chromatin condensation.
This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein (XNP). This protein may play a role in the hematopoietic and central nervous systems. Two transcript variants encoding distinct isoforms have been identified for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPK073Hu01 Recombinant Enhancer Of Zeste Homolog 2 (EZH2) Positive Control; Immunogen; SDS-PAGE; WB.
RPK073Hu02 Recombinant Enhancer Of Zeste Homolog 2 (EZH2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAK073Hu01 Polyclonal Antibody to Enhancer Of Zeste Homolog 2 (EZH2) WB; IHC; ICC; IP.
PAK073Hu02 Polyclonal Antibody to Enhancer Of Zeste Homolog 2 (EZH2) WB; IHC; ICC; IP.
Assay Kits SEK073Hu ELISA Kit for Enhancer Of Zeste Homolog 2 (EZH2) Enzyme-linked immunosorbent assay for Antigen Detection.
SCK073Hu CLIA Kit for Enhancer Of Zeste Homolog 2 (EZH2) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Enhancer Of Zeste Homolog 2 (EZH2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Enhancer Of Zeste Homolog 2 (EZH2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Enhancer Of Zeste Homolog 2 (EZH2) Polyclonal Antibody Customized Service Offer
Assay Kits SEK073Mu ELISA Kit for Enhancer Of Zeste Homolog 2 (EZH2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Enhancer Of Zeste Homolog 2 (EZH2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Enhancer Of Zeste Homolog 2 (EZH2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Enhancer Of Zeste Homolog 2 (EZH2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Enhancer Of Zeste Homolog 2 (EZH2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Enhancer Of Zeste Homolog 2 (EZH2) ELISA Kit Customized Service Offer
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  16. "Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27."Genes Dev. 18:1592-1605(2004) [PubMed] [Europe PMC] [Abstract]
  17. "Different EZH2-containing complexes target methylation of histone H1 or nucleosomal histone H3."Mol. Cell 14:183-193(2004) [PubMed] [Europe PMC] [Abstract]
  18. "SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex."Mol. Cell 15:57-67(2004) [PubMed] [Europe PMC] [Abstract]
  19. "Activated p53 suppresses the histone methyltransferase EZH2 gene."Oncogene 23:5759-5769(2004) [PubMed] [Europe PMC] [Abstract]
  20. "The human tumor antigen PRAME is a dominant repressor of retinoic acid receptor signaling."Cell 122:835-847(2005) [PubMed] [Europe PMC] [Abstract]
  21. "Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation."Proc. Natl. Acad. Sci. U.S.A. 102:1859-1864(2005) [PubMed] [Europe PMC] [Abstract]
  22. "Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3."Science 310:306-310(2005) [PubMed] [Europe PMC] [Abstract]
  23. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
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  25. "Substrate preferences of the EZH2 histone methyltransferase complex."J. Biol. Chem. 281:8365-8370(2006) [PubMed] [Europe PMC] [Abstract]
  26. "The polycomb group protein EZH2 is required for mammalian circadian clock function."J. Biol. Chem. 281:21209-21215(2006) [PubMed] [Europe PMC] [Abstract]
  27. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  28. "The Polycomb group protein EZH2 directly controls DNA methylation."Nature 439:871-874(2006) [PubMed] [Europe PMC] [Abstract]
  29. ErratumNature 446:824-824(2006)
  30. "Argonaute-1 directs siRNA-mediated transcriptional gene silencing in human cells."Nat. Struct. Mol. Biol. 13:793-797(2006) [PubMed] [Europe PMC] [Abstract]
  31. "pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4alpha tumor suppressor gene."Genes Dev. 21:49-54(2007) [PubMed] [Europe PMC] [Abstract]
  32. "The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells."Genes Dev. 21:525-530(2007) [PubMed] [Europe PMC] [Abstract]
  33. "Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer."Nat. Genet. 39:232-236(2007) [PubMed] [Europe PMC] [Abstract]
  34. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  35. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  36. "Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms."Mol. Cell 32:503-518(2008) [PubMed] [Europe PMC] [Abstract]
  37. "Role of hPHF1 in H3K27 methylation and Hox gene silencing."Mol. Cell. Biol. 28:1862-1872(2008) [PubMed] [Europe PMC] [Abstract]
  38. "Ezh2 requires PHF1 to efficiently catalyze H3 lysine 27 trimethylation in vivo."Mol. Cell. Biol. 28:2718-2731(2008) [PubMed] [Europe PMC] [Abstract]
  39. "The polycomb repressive complex 2 is a potential target of SUMO modifications."PLoS ONE 3:E2704-E2704(2008) [PubMed] [Europe PMC] [Abstract]
  40. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  41. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  42. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  43. "Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2."Nat. Cell Biol. 12:1108-1114(2010) [PubMed] [Europe PMC] [Abstract]
  44. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  45. "Corepressor protein CDYL functions as a molecular bridge between polycomb repressor complex 2 and repressive chromatin mark trimethylated histone lysine 27."J. Biol. Chem. 286:42414-42425(2011) [PubMed] [Europe PMC] [Abstract]
  46. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  47. "EZH2 generates a methyl degron that is recognized by the DCAF1/DDB1/CUL4 E3 ubiquitin ligase complex."Mol. Cell 48:572-586(2012) [PubMed] [Europe PMC] [Abstract]
  48. "O-GlcNAcylation regulates EZH2 protein stability and function."Proc. Natl. Acad. Sci. U.S.A. 111:1355-1360(2014) [PubMed] [Europe PMC] [Abstract]
  49. "Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin." Nat. Genet. 42:181-185(2010) [PubMed] [Europe PMC] [Abstract]
  50. "Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A."Blood 118:3932-3941(2011) [PubMed] [Europe PMC] [Abstract]
  51. "Mutations in EZH2 cause Weaver syndrome."Am. J. Hum. Genet. 90:110-118(2012) [PubMed] [Europe PMC] [Abstract]