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SON DNA Binding Protein (SON)

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BASS1; DBP-5; NREBP; SON3; NRE-Binding Protein; Negative Regulatory Element-Binding Protein; Bax Antagonist Selected in Saccharomyces 1

SON DNA Binding Protein (SON)
CCC K071
HGNC 11183
MGI 98353
PubMed 23322776
RGD 1309013
UniProt P18583
Wiki SON
SON DNA Binding Protein binds to a specific DNA sequence upstream of the upstream regulatory sequence of the core promoter and second enhancer of human hepatitis B virus (HBV). Through this binding, it represses HBV core promoter activity, transcription of HBV genes, and production of HBV virions.
The protein shows sequence similarities with other DNA-binding structural proteins such as gallin, oncoproteins of the MYC family, and the oncoprotein MOS. It may also be involved in protecting cells from apoptosis and in pre-mRNA splicing. Several transcript variants encoding different isoforms have been described for this gene, but the full-length nature of only two of them has been determined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SON DNA Binding Protein (SON) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SON DNA Binding Protein (SON) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SON DNA Binding Protein (SON) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SON DNA Binding Protein (SON) CLIA Kit Customized Service Offer
n/a ELISA Kit for SON DNA Binding Protein (SON) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SON DNA Binding Protein (SON) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SON DNA Binding Protein (SON) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SON DNA Binding Protein (SON) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SON DNA Binding Protein (SON) CLIA Kit Customized Service Offer
n/a ELISA Kit for SON DNA Binding Protein (SON) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SON DNA Binding Protein (SON) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SON DNA Binding Protein (SON) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SON DNA Binding Protein (SON) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SON DNA Binding Protein (SON) CLIA Kit Customized Service Offer
n/a ELISA Kit for SON DNA Binding Protein (SON) ELISA Kit Customized Service Offer
  1. "From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map."Genomics 78:46-54(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Transcription repression of human hepatitis B virus genes by negative regulatory element-binding protein/SON."J. Biol. Chem. 276:24059-24067(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence of human chromosome 21." Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
  5. "mRNA 5' region sequence incompleteness: a potential source of systematic errors in translation initiation codon assignment in human mRNAs."Gene 321:185-193(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Identification of a protein product of a novel human gene SON and the biological effect upon administering a changed form of this gene into mammalian cells."Mol. Biol. (Mosk.) 25:731-740(1991) [PubMed] [Europe PMC] [Abstract]
  9. "The human SON gene: the large and small transcripts contains various 5'-terminal sequences."Mol. Biol. (Mosk.) 26:807-812(1992) [PubMed] [Europe PMC] [Abstract]
  10. "Coding part of the son gene small transcript contains four areas of complete tandem repeats."Mol. Biol. (Mosk.) 26:793-806(1992) [PubMed] [Europe PMC] [Abstract]
  11. "A cDNA clone for a novel nuclear protein with DNA binding activity."Chromosoma 101:618-624(1992) [PubMed] [Europe PMC] [Abstract]
  12. "Decoding of the primary structure of the son3 region in human genome: identification of a new protein with unusual structure and homology with DNA-binding proteins."Mol. Biol. (Mosk.) 22:794-801(1988) [PubMed] [Europe PMC] [Abstract]
  13. "A selection system for human apoptosis inhibitors using yeast."Yeast 15:1307-1321(1999) [PubMed] [Europe PMC] [Abstract]
  14. "An unappreciated role for RNA surveillance."Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
  15. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  16. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Disruption of the NHR4 domain structure in AML1-ETO abrogates SON binding and promotes leukemogenesis."Proc. Natl. Acad. Sci. U.S.A. 105:17103-17108(2008) [PubMed] [Europe PMC] [Abstract]
  18. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  21. "SON is a spliceosome-associated factor required for mitotic progression."Cell Cycle 9:2679-2685(2010) [PubMed] [Europe PMC] [Abstract]
  22. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  23. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  24. "SON controls cell-cycle progression by coordinated regulation of RNA splicing."Mol. Cell 42:185-198(2011) [PubMed] [Europe PMC] [Abstract]
  25. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  26. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  27. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]