≡

Budding Uninhibited By Benzimidazoles 3 (BUB3)

[Edit]

BUB3L; hBUB3; Mitotic checkpoint protein BUB3

Budding Uninhibited By Benzimidazoles 3 (BUB3)
CCC K068
HGNC 1151
MGI 1343463
PubMed 10411903
UniProt O43684
Wiki BUB3
Bub3 is a protein involved with the regulation of the Spindle Assembly Checkpoint (SAC); though BUB3 is non-essential in yeast, it is essential in higher eukaryotes. As one of the checkpoint proteins, Bub3 delays the irreversible onset of anaphase through direction of kinetochore localization during prometaphase to achieve biorentation. In directing the kinetochore-microtubule interaction, this ensures the proper attachment of the chromosomes prior to anaphase.
Bub3 and its related proteins that form the Spindle Assembly Checkpoint (SAC) inhibit the action of the Anaphase Promoting Complex (APC), preventing early anaphase entry and mitotic exit; this serves as a mechanism for the fidelity of chromosomal segregation

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Budding Uninhibited By Benzimidazoles 3 (BUB3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Budding Uninhibited By Benzimidazoles 3 (BUB3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Budding Uninhibited By Benzimidazoles 3 (BUB3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Budding Uninhibited By Benzimidazoles 3 (BUB3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Budding Uninhibited By Benzimidazoles 3 (BUB3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Budding Uninhibited By Benzimidazoles 3 (BUB3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Budding Uninhibited By Benzimidazoles 3 (BUB3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Budding Uninhibited By Benzimidazoles 3 (BUB3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Budding Uninhibited By Benzimidazoles 3 (BUB3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Budding Uninhibited By Benzimidazoles 3 (BUB3) ELISA Kit Customized Service Offer
  1. "Phosphorylation of human MAD1 by the BUB1 kinase in vitro."Biochem. Biophys. Res. Commun. 257:589-595(1999) [PubMed] [Europe PMC] [Abstract]
  2. "The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase."J. Cell Biol. 142:1-11(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint."Mol. Cell 16:387-397(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The human spindle assembly checkpoint protein Bub3 is required for the establishment of efficient kinetochore-microtubule attachments."Mol. Biol. Cell 19:1798-1813(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "A microtubule-associated zinc finger protein, BuGZ, regulates mitotic chromosome alignment by ensuring Bub3 stability and kinetochore targeting."Dev. Cell 28:268-281(2014) [PubMed] [Europe PMC] [Abstract]
  12. "BuGZ is required for Bub3 stability, Bub1 kinetochore function, and chromosome alignment."Dev. Cell 28:282-294(2014) [PubMed] [Europe PMC] [Abstract]