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Four And A Half LIM Domains Protein 2 (FHL2)

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AAG11; DRAL; SLIM3; LIM domain protein DRAL; Skeletal muscle LIM-protein 3

Four And A Half LIM Domains Protein 2 (FHL2)
CCC K065
HGNC 3703
MGI 1338762
PubMed 23413425
RGD 61963
UniProt Q14192
Wiki FHL2
FHL2 protein contains 279 amino acids and has a calculated molecular mass of about 32 kD.The gene, termed DRAL for 'down-regulated in rhabdomyosarcoma LIM protein,' encodes a 279-amino acid polypeptide with an observed mass of 32 kD. The protein sequence contains 4 complete LIM domains and the second half of a fifth LIM domain. DRAL appears to be a member of the LIM-only class of proteins, which consist primarily of LIM domains and little else. Southern blotting revealed a single-copy gene that is conserved among vertebrates. FHL2 immunoreactivity is confined almost entirely to the cell membranes. FHL2 also localized to the basal cell compartment. In undifferentiated prostate carcinoma, FHL2 was overexpressed and staining redistributed to the cytoplasm and nuclei of tumor cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Four And A Half LIM Domains Protein 2 (FHL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Four And A Half LIM Domains Protein 2 (FHL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Four And A Half LIM Domains Protein 2 (FHL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Four And A Half LIM Domains Protein 2 (FHL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Four And A Half LIM Domains Protein 2 (FHL2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Four And A Half LIM Domains Protein 2 (FHL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Four And A Half LIM Domains Protein 2 (FHL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Four And A Half LIM Domains Protein 2 (FHL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Four And A Half LIM Domains Protein 2 (FHL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Four And A Half LIM Domains Protein 2 (FHL2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Four And A Half LIM Domains Protein 2 (FHL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Four And A Half LIM Domains Protein 2 (FHL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Four And A Half LIM Domains Protein 2 (FHL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Four And A Half LIM Domains Protein 2 (FHL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Four And A Half LIM Domains Protein 2 (FHL2) ELISA Kit Customized Service Offer
  1. "Subtractive cloning and characterization of DRAL, a novel LIM-domain protein down-regulated in rhabdomyosarcoma."DNA Cell Biol. 16:433-442(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning and characterization of FHL2, a novel LIM domain protein preferentially expressed in human heart."Gene 210:345-350(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Alzheimer's disease-associated presenilin 2 interacts with DRAL, an LIM-domain protein."Hum. Mol. Genet. 9:2281-2289(2000) [PubMed] [Europe PMC] [Abstract]
  4. "FHL3 negatively regulates human high-affinity IgE receptor beta-chain gene expression by acting as a transcriptional co-repressor of MZF-1."Biochem. J. 386:191-200(2005) [PubMed] [Europe PMC] [Abstract]
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Slim defines a novel family of LIM-proteins expressed in skeletal muscle."Biochem. Biophys. Res. Commun. 225:632-638(1996) [PubMed] [Europe PMC] [Abstract]
  8. "Interaction of the heart-specific LIM domain protein, FHL2, with DNA-binding nuclear protein, hNP220."J. Cell. Biochem. 84:556-566(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Subcellular targeting of metabolic enzymes to titin in heart muscle may be mediated by DRAL/FHL-2."J. Cell Sci. 115:4925-4936(2002) [PubMed] [Europe PMC] [Abstract]
  10. "Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation."EMBO J. 24:1021-1032(2005) [PubMed] [Europe PMC] [Abstract]
  11. "The LIM-only protein FHL2 is a negative regulator of E4F1."Oncogene 25:5475-5484(2006) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "The cell migration protein Grb7 associates with transcriptional regulator FHL2 in a Grb7 phosphorylation-dependent manner."J. Mol. Recognit. 22:9-17(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Solution structure of LIM domains in LIM-protein 3."Submitted (JUN-2006) to the PDB data bank