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Cyclin D-Type Binding Protein 1 (CCNDBP1)

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DIP1; HHM; GCIP; D-Type Cyclin-Interacting Protein 1; MAID Protein; HHM Protein; Grap2 Cyclin Interacting Protein; Grap2 and cyclin-D-interacting protein

Cyclin D-Type Binding Protein 1 (CCNDBP1)
CCC K044
HGNC 1587
MGI 109595
PubMed 22453338
RGD 1304669
UniProt O95273
Wiki CCNDBP1
CCNDBP1 was identified by the interaction of its gene product with Grap2, a leukocyte-specific adaptor protein important for immune cell signaling. The protein encoded by this gene was shown to interact with cyclin D. Transfection of this gene in cells was reported to reduce the phosphorylation of Rb gene product by cyclin D-dependent protein kinase, and inhibit E2F1-mediated transcription activity.
This protein was also found to interact with helix-loop-helix protein E12 and is thought to be a negative regulator of liver-specific gene expression. Two alternatively spliced variants, which encode distinct isoforms, have been reported. CCNDBP1 encodes a deduced 360-amino acid protein with a calculated molecular mass of 40 kD.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cyclin D-Type Binding Protein 1 (CCNDBP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cyclin D-Type Binding Protein 1 (CCNDBP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cyclin D-Type Binding Protein 1 (CCNDBP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cyclin D-Type Binding Protein 1 (CCNDBP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclin D-Type Binding Protein 1 (CCNDBP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cyclin D-Type Binding Protein 1 (CCNDBP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cyclin D-Type Binding Protein 1 (CCNDBP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cyclin D-Type Binding Protein 1 (CCNDBP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cyclin D-Type Binding Protein 1 (CCNDBP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclin D-Type Binding Protein 1 (CCNDBP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cyclin D-Type Binding Protein 1 (CCNDBP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cyclin D-Type Binding Protein 1 (CCNDBP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cyclin D-Type Binding Protein 1 (CCNDBP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cyclin D-Type Binding Protein 1 (CCNDBP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclin D-Type Binding Protein 1 (CCNDBP1) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of DIP1, a novel protein that is related to the Id family of proteins."Exp. Cell Res. 257:22-32(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Human homologue of maid: a dominant inhibitory helix-loop-helix protein associated with liver-specific gene expression."Hepatology 32:357-366(2000) [PubMed] [Europe PMC] [Abstract]
  3. "GCIP, a novel human grap2 and cyclin D interacting protein, regulates E2F-mediated transcriptional activity."J. Biol. Chem. 275:20942-20948(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "p29, a novel GCIP-interacting protein, localizes in the nucleus."Biochem. Biophys. Res. Commun. 279:732-737(2000) [PubMed] [Europe PMC] [Abstract]
  9. "Human homologue of maid is a useful marker protein in hepatocarcinogenesis."Gastroenterology 128:1369-1380(2005) [PubMed] [Europe PMC] [Abstract]
  10. "GCIP/CCNDBP1, a helix-loop-helix protein, suppresses tumorigenesis."J. Cell. Biochem. 100:1376-1386(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Ribosomal phosphoprotein P0 interacts with GCIP and overexpression of P0 is associated with cellular proliferation in breast and liver carcinoma cells."Oncogene 27:332-338(2008) [PubMed] [Europe PMC] [Abstract]
  12. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]