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Formin Binding Protein 2 (FNBP2)

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SRGAP2; ARHGAP34; SRGAP2A; SLIT-ROBO Rho GTPase Activating Protein 2; Rho GTPase-activating protein 34

Formin Binding Protein 2 (FNBP2)
CCC K038
HGNC 19751
MGI 109605
PubMed 12736724
UniProt O75044
The FNBP2 has 1,095 amino acids and is 35.7% identical to C1 RHOGAP. It was predicted to be involved in cell signaling/communication. RT-PCR analysis detected low-level expression of KIAA0456 in placenta, kidney, and ovary, with little or no expression in all other tissues tested.
The centrally located RHOGAP domain in SRGAP2 is highly similar to the RHOGAP domains of SRGAP1, SRGAP3, and C1 RHOGAP. The SH3 domain in SRGAP2 is similar to those in SRGAP1, SRGAP3, C1 RHOGAP, and CSK. Northern blot analysis detected SRGAP2 transcripts of 9.5, 8.0, and 4.4 kb in all tissues tested, with the 4.4-kb transcript being the most abundant. In situ hybridization of rodent tissues showed that Srgap1 and Srgap2 are expressed in regions responsive to Slit.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Formin Binding Protein 2 (FNBP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Formin Binding Protein 2 (FNBP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Formin Binding Protein 2 (FNBP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Formin Binding Protein 2 (FNBP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Formin Binding Protein 2 (FNBP2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Formin Binding Protein 2 (FNBP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Formin Binding Protein 2 (FNBP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Formin Binding Protein 2 (FNBP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Formin Binding Protein 2 (FNBP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Formin Binding Protein 2 (FNBP2) ELISA Kit Customized Service Offer
  1. "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain."DNA Res. 4:345-349(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway."Cell 107:209-221(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  4. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract]
  7. "srGAP2 arginine methylation regulates cell migration and cell spreading through promoting dimerization."J. Biol. Chem. 285:35133-35141(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Early infantile epileptic encephalopathy associated with the disrupted gene encoding Slit-Robo Rho GTPase activating protein 2 (SRGAP2)."Am. J. Med. Genet. A 158A:199-205(2012) [PubMed] [Europe PMC] [Abstract]
  12. "Bi-modal regulation of a formin by srGAP2."J. Biol. Chem. 286:6577-6586(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Inhibition of SRGAP2 function by its human-specific paralogs induces neoteny during spine maturation."Cell 149:923-935(2012) [PubMed] [Europe PMC] [Abstract]
  14. "The F-BAR domains from srGAP1, srGAP2, and srGAP3 differentially regulate membrane deformation."J. Cell Sci. 125:3390-3401(2012) [PubMed] [Europe PMC] [Abstract]
  15. "Solution structure of the SH3 domain of human SLIT-ROBO Rho GTPase-activating protein 2."Submitted (OCT-2006) to the PDB data bank