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RAB8A, Member RAS Oncogene Family (RAB8A)

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MEL; RAB8; Oncogene c-mel; Ras-related protein Rab-8A

RAB8A, Member RAS Oncogene Family (RAB8A)
CCC K037
HGNC 7007
MGI 96960
PubMed 21596566
UniProt P61006
Wiki RAB8A
RAB8A is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane.
This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAB8A, Member RAS Oncogene Family (RAB8A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAB8A, Member RAS Oncogene Family (RAB8A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAB8A, Member RAS Oncogene Family (RAB8A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAB8A, Member RAS Oncogene Family (RAB8A) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAB8A, Member RAS Oncogene Family (RAB8A) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAB8A, Member RAS Oncogene Family (RAB8A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAB8A, Member RAS Oncogene Family (RAB8A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAB8A, Member RAS Oncogene Family (RAB8A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAB8A, Member RAS Oncogene Family (RAB8A) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAB8A, Member RAS Oncogene Family (RAB8A) ELISA Kit Customized Service Offer
  1. "A small rab GTPase is distributed in cytoplasmic vesicles in non polarized cells but colocalizes with the tight junction marker ZO-1 in polarized epithelial cells."J. Cell Biol. 124:101-115(1994) [PubMed] [Europe PMC] [Abstract]
  2. "The MEL gene: a new member of the RAB/YPT class of RAS-related genes."Oncogene 6:1347-1351(1991) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Isoprenylation of Rab proteins possessing a C-terminal CaaX motif."FEBS Lett. 330:323-328(1993) [PubMed] [Europe PMC] [Abstract]
  7. "A Rab8-specific GDP/GTP exchange factor is involved in actin remodeling and polarized membrane transport."Mol. Biol. Cell 13:3268-3280(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosis."J. Cell Biol. 169:285-295(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Final stages of cytokinesis and midbody ring formation are controlled by BRUCE."Cell 132:832-845(2008) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Pitchfork regulates primary cilia disassembly and left-right asymmetry."Dev. Cell 19:66-77(2010) [PubMed] [Europe PMC] [Abstract]
  14. "A molecular network for de novo generation of the apical surface and lumen."Nat. Cell Biol. 12:1035-1045(2010) [PubMed] [Europe PMC] [Abstract]
  15. "MICAL-L1 links EHD1 to tubular recycling endosomes and regulates receptor recycling."Mol. Biol. Cell 20:5181-5194(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  18. "Rab GTPase-Myo5B complexes control membrane recycling and epithelial polarization."Proc. Natl. Acad. Sci. U.S.A. 108:2789-2794(2011) [PubMed] [Europe PMC] [Abstract]
  19. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  20. "Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes."Traffic 12:407-420(2011) [PubMed] [Europe PMC] [Abstract]
  21. "A SNX10/V-ATPase pathway regulates ciliogenesis in vitro and in vivo."Cell Res. 22:333-345(2012) [PubMed] [Europe PMC] [Abstract]
  22. "OCRL localizes to the primary cilium: a new role for cilia in Lowe syndrome."Hum. Mol. Genet. 21:3333-3344(2012) [PubMed] [Europe PMC] [Abstract]
  23. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  24. "A structural basis for Lowe syndrome caused by mutations in the Rab-binding domain of OCRL1."EMBO J. 30:1659-1670(2011) [PubMed] [Europe PMC] [Abstract]