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Intraflagellar Transport Protein 57 (IFT57)

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ESRRBL1; HIPPI; MHS4R2; DERP8; Estrogen-Related Receptor Beta Like 1; Dermal papilla-derived protein 8; HIP1-interacting protein

Intraflagellar Transport Protein 57 (IFT57)
CCC K036
HGNC 17367
MGI 1921166
PubMed 18492793
RGD 1305947
UniProt Q9NWB7
Wiki IFT57
The C terminus shows weak similarity to some cytoskeletal proteins such as the Rho-associated kinase ROCK2. HIPPI mRNA is expressed in the brain. It is present in all regions of the brain, and to a lesser extent in spinal cord. It is also expressed abundantly in heart, kidney, and lung, with weaker expression in all other tissues tested. HIPPI is expressed in the Golgi apparatus of neurons where it partly colocalizes with HIP1. Immunohistochemical studies in mice revealed that HIPPI is present in neurons and neuropil throughout the brain. Within the Golgi, HIPPI was found on the outside of cisternae and mostly in the cis-Golgi. This observation was confirmed in human neuronal NT2 cells. HIPPI was found to be expressed in cortico-striatal and striato-pallidal projection neurons.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Intraflagellar Transport Protein 57 (IFT57) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Intraflagellar Transport Protein 57 (IFT57) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Intraflagellar Transport Protein 57 (IFT57) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Intraflagellar Transport Protein 57 (IFT57) CLIA Kit Customized Service Offer
n/a ELISA Kit for Intraflagellar Transport Protein 57 (IFT57) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Intraflagellar Transport Protein 57 (IFT57) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Intraflagellar Transport Protein 57 (IFT57) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Intraflagellar Transport Protein 57 (IFT57) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Intraflagellar Transport Protein 57 (IFT57) CLIA Kit Customized Service Offer
n/a ELISA Kit for Intraflagellar Transport Protein 57 (IFT57) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Intraflagellar Transport Protein 57 (IFT57) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Intraflagellar Transport Protein 57 (IFT57) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Intraflagellar Transport Protein 57 (IFT57) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Intraflagellar Transport Protein 57 (IFT57) CLIA Kit Customized Service Offer
n/a ELISA Kit for Intraflagellar Transport Protein 57 (IFT57) ELISA Kit Customized Service Offer
  1. "Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi."Nat. Cell Biol. 4:95-105(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The viral death protein Apoptin interacts with Hippi, the protein interactor of Huntingtin-interacting protein 1."Biochem. Biophys. Res. Commun. 305:359-364(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Bifunctional apoptosis inhibitor (BAR) protects neurons from diverse cell death pathways."Cell Death Differ. 10:1178-1187(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Homer1c interacts with Hippi and protects striatal neurons from apoptosis."Biochem. Biophys. Res. Commun. 352:1-5(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Interaction of HIPPI with putative promoter sequence of caspase-1 in vitro and in vivo."Biochem. Biophys. Res. Commun. 353:80-85(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Interactions of HIPPI, a molecular partner of Huntingtin interacting protein HIP1, with the specific motif present at the putative promoter sequence of the caspase-1, caspase-8 and caspase-10 genes."FEBS J. 274:3886-3899(2007) [PubMed] [Europe PMC] [Abstract]