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SET Domain Containing Protein 2 (SETD2)

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HYPB; KMT3A; HIF1; SET2; HIP-1; Huntingtin yeast partner B; Huntingtin-interacting protein 1; Lysine N-methyltransferase 3A; Histone-lysine N-methyltransferase SETD2

SET Domain Containing Protein 2 (SETD2)
CCC K033
HGNC 18420
MGI 1918177
PubMed 23417712
RGD 1305576
UniProt Q9BYW2
Wiki SETD2
The deduced 2,061-amino acid protein has a calculated molecular mass of about 231 kD. It has a putative N-terminal tyrosine phosphorylation site, a central SET domain, and a C-terminal WW/WWP domain that is followed by a putative nuclear localization signal. The C-terminal region of HBP231 corresponds to the HYPB sequence. Northern blot analysis detected a 7.5-kb transcript expressed at variable levels in all tissues examined. Western blot analysis of HeLa cells showed that HBP231 had an apparent molecular mass of 231 kD.
The deduced protein contains 1,325 amino acids. RT-PCR detected low SETD2 expression in all adult and fetal tissues and specific adult brain regions examined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SET Domain Containing Protein 2 (SETD2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SET Domain Containing Protein 2 (SETD2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SET Domain Containing Protein 2 (SETD2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SET Domain Containing Protein 2 (SETD2) CLIA Kit Customized Service Offer
n/a ELISA Kit for SET Domain Containing Protein 2 (SETD2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SET Domain Containing Protein 2 (SETD2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SET Domain Containing Protein 2 (SETD2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SET Domain Containing Protein 2 (SETD2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SET Domain Containing Protein 2 (SETD2) CLIA Kit Customized Service Offer
n/a ELISA Kit for SET Domain Containing Protein 2 (SETD2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SET Domain Containing Protein 2 (SETD2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SET Domain Containing Protein 2 (SETD2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SET Domain Containing Protein 2 (SETD2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SET Domain Containing Protein 2 (SETD2) CLIA Kit Customized Service Offer
n/a ELISA Kit for SET Domain Containing Protein 2 (SETD2) ELISA Kit Customized Service Offer
  1. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "Identification of the full-length huntingtin-interacting protein p231HBP/HYPB as a DNA-binding factor."Mol. Cell. Neurosci. 18:68-79(2001) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Identification and characterization of a novel human histone H3 lysine 36 specific methyltransferase."J. Biol. Chem. 280:35261-35271(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
  8. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Huntingtin interacts with a family of WW domain proteins."Hum. Mol. Genet. 7:1463-1474(1998) [PubMed] [Europe PMC] [Abstract]
  11. "Huntingtin's WW domain partners in Huntington's disease post-mortem brain fulfill genetic criteria for direct involvement in Huntington's disease pathogenesis."Hum. Mol. Genet. 9:2175-2182(2000) [PubMed] [Europe PMC] [Abstract]
  12. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Histone methyltransferase protein SETD2 interacts with p53 and selectively regulates its downstream genes."Cell. Signal. 20:1671-1678(2008) [PubMed] [Europe PMC] [Abstract]
  14. "The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation."Genes Dev. 22:3422-3434(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  16. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Heterogeneous nuclear ribonucleoprotein L is a subunit of human KMT3a/Set2 complex required for H3 Lys-36 trimethylation activity in vivo."J. Biol. Chem. 284:15701-15707(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes." Nature 463:360-363(2010) [PubMed] [Europe PMC] [Abstract]
  21. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  22. "Splicing enhances recruitment of methyltransferase HYPB/Setd2 and methylation of histone H3 Lys36."Nat. Struct. Mol. Biol. 18:977-983(2011) [PubMed] [Europe PMC] [Abstract]
  23. "Relationship between gene body DNA methylation and intragenic H3K9me3 and H3K36me3 chromatin marks."PLoS ONE 6:E18844-E18844(2011) [PubMed] [Europe PMC] [Abstract]
  24. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  25. "The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutSalpha."Cell 153:590-600(2013) [PubMed] [Europe PMC] [Abstract]
  26. "Comprehensive molecular characterization of clear cell renal cell carcinoma." Nature 499:43-49(2013) [PubMed] [Europe PMC] [Abstract]
  27. "Histone methyltransferase SETD2 coordinates FACT recruitment with nucleosome dynamics during transcription."Nucleic Acids Res. 41:2881-2893(2013) [PubMed] [Europe PMC] [Abstract]
  28. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  29. "Solution structure of the Set2-Rpb1 interacting domain of human Set2 and its interaction with the hyperphosphorylated C-terminal domain of Rpb1."Proc. Natl. Acad. Sci. U.S.A. 102:17636-17641(2005) [PubMed] [Europe PMC] [Abstract]
  30. "Sinefungin derivatives as inhibitors and structure probes of protein lysine methyltransferase SETD2."J. Am. Chem. Soc. 134:18004-18014(2012) [PubMed] [Europe PMC] [Abstract]