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Kalirin (KALRN)

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DUO; HAPIP; TRAD; DUET; Huntingtin-Associated Protein Interacting Protein; Serine/Threonine Kinase With Dbl And Pleckstrin Homology Domains

Kalirin (KALRN)
CCC K031
HGNC 4814
MGI 2685385
PubMed 22548195
RGD 621865
UniProt O60229
Wiki Kalirin
Kalirin is a member of Dbl family of proteins and a Rho guanine nucleotide exchange factor. It is named after the multiple-handed Hindu goddess Kali for its ability to interact with numerous other proteins. Kalirin's other name, DUO, comes from the fact that it is 98% identical to rat DUO protein and 80.6% identical to a human protein named TRIO. Unlike TRIO, which is expressed in numerous tissues, Kalirin isoforms are mainly found in the brain. Several isoforms of Kalirin are produced through alternative splicing.One of the isoforms, Kalirin-7, was found to be necessary for the remodeling of synapses in mature cortical neurons and is thought to be important in the development of schizophrenia, as demonstrated by adolescent development of schizophrenia-like symptoms in kalirin knockout mice.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kalirin (KALRN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kalirin (KALRN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kalirin (KALRN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kalirin (KALRN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kalirin (KALRN) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kalirin (KALRN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kalirin (KALRN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kalirin (KALRN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kalirin (KALRN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kalirin (KALRN) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kalirin (KALRN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kalirin (KALRN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kalirin (KALRN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kalirin (KALRN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kalirin (KALRN) ELISA Kit Customized Service Offer
  1. "Huntingtin-associated protein 1 (HAP1) binds to a Trio-like polypeptide, with a rac1 guanine nucleotide exchange factor domain."Hum. Mol. Genet. 6:1519-1525(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Duet is a novel serine/threonine kinase with Dbl-homology (DH) and pleckstrin-homology (PH) domains."Gene 227:249-255(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Peakwide mapping on chromosome 3q13 identifies the kalirin gene as a novel candidate gene for coronary artery disease."Am. J. Hum. Genet. 80:650-663(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Structural organization of the nine spectrin repeats of Kalirin."Biochemistry 51:5663-5673(2012) [PubMed] [Europe PMC] [Abstract]
  12. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]