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SATB Homeobox Protein 1 (SATB1)

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DNA-binding protein SATB1; Special AT-Rich Sequence Binding Protein 1(Binds To Nuclear Matrix/Scaffold-Associating DNA's)

SATB Homeobox Protein 1 (SATB1)
CCC K006
HGNC 10541
MGI 105084
PubMed 23791645
RGD 1305561
UniProt Q01826
Wiki SATB1
SATB1, the global chromatin organizer and transcription factor, has emerged as a key factor integrating higher-order chromatin architecture with gene regulation. Recent studies have unraveled the role of SATB1 in organization of chromatin 'loopscape' and its dynamic nature in response to physiological stimuli. At genome-wide level, SATB1 seems to play a role in organization of the transcriptionally poised chromatin. SATB1 organizes the MHC class-I locus into distinct chromatin loops by tethering MARs to nuclear matrix at fixed distances. Silencing of SATB1 mimics the effects of IFN-γ treatment on chromatin loop architecture of the MHC class I locus and altered expression of genes within the locus. SATB1induce breast cancer tumor growth and metastasis through the altered expression of large numbers of genes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPK006Hu01 Recombinant SATB Homeobox Protein 1 (SATB1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAK006Hu01 Polyclonal Antibody to SATB Homeobox Protein 1 (SATB1) WB; IHC; ICC; IP.
MAK006Hu21 Monoclonal Antibody to SATB Homeobox Protein 1 (SATB1) WB; IHC; ICC; IP.
Assay Kits SEK006Hu ELISA Kit for SATB Homeobox Protein 1 (SATB1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SATB Homeobox Protein 1 (SATB1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SATB Homeobox Protein 1 (SATB1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SATB Homeobox Protein 1 (SATB1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SATB Homeobox Protein 1 (SATB1) CLIA Kit Customized Service Offer
n/a ELISA Kit for SATB Homeobox Protein 1 (SATB1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SATB Homeobox Protein 1 (SATB1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SATB Homeobox Protein 1 (SATB1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SATB Homeobox Protein 1 (SATB1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SATB Homeobox Protein 1 (SATB1) CLIA Kit Customized Service Offer
n/a ELISA Kit for SATB Homeobox Protein 1 (SATB1) ELISA Kit Customized Service Offer
  1. "A tissue-specific MAR/SAR DNA-binding protein with unusual binding site recognition."Cell 70:631-645(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "An atypical homeodomain in SATB1 promotes specific recognition of the key structural element in a matrix attachment region."J. Biol. Chem. 272:11463-11470(1997) [PubMed] [Europe PMC] [Abstract]
  6. "The genomic sequences bound to special AT-rich sequence-binding protein 1 (SATB1) in vivo in Jurkat T cells are tightly associated with the nuclear matrix at the bases of the chromatin loops."J. Cell Biol. 141:335-348(1998) [PubMed] [Europe PMC] [Abstract]
  7. "The gammaPE complex contains both SATB1 and HOXB2 and has positive and negative roles in human gamma-globin gene regulation."DNA Cell Biol. 18:805-817(1999) [PubMed] [Europe PMC] [Abstract]
  8. "The fate of the nuclear matrix-associated-region-binding protein SATB1 during apoptosis."Cell Death Differ. 7:425-438(2000) [PubMed] [Europe PMC] [Abstract]
  9. "SATB1 cleavage by caspase 6 disrupts PDZ domain-mediated dimerization, causing detachment from chromatin early in T-cell apoptosis."Mol. Cell. Biol. 21:5591-5604(2001) [PubMed] [Europe PMC] [Abstract]
  10. "The thymocyte-specific MAR binding protein, SATB1, interacts in vitro with a novel variant of DNA-directed RNA polymerase II, subunit 11."Genomics 79:809-817(2002) [PubMed] [Europe PMC] [Abstract]
  11. "SATB1 targets chromatin remodelling to regulate genes over long distances."Nature 419:641-645(2002) [PubMed] [Europe PMC] [Abstract]
  12. "SATB1 makes a complex with p300 and represses gp91(phox) promoter activity."Microbiol. Immunol. 47:803-811(2003) [PubMed] [Europe PMC] [Abstract]
  13. "Tissue-specific nuclear architecture and gene expression regulated by SATB1."Nat. Genet. 34:42-51(2003) [PubMed] [Europe PMC] [Abstract]
  14. "SATB1 family protein expressed during early erythroid differentiation modifies globin gene expression."Blood 105:3330-3339(2005) [PubMed] [Europe PMC] [Abstract]
  15. "A nuclear targeting determinant for SATB1, a genome organizer in the T cell lineage."Cell Cycle 4:1099-1106(2005) [PubMed] [Europe PMC] [Abstract]
  16. "Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates."J. Biol. Chem. 280:5004-5012(2005) [PubMed] [Europe PMC] [Abstract]
  17. "Nuclear matrix binding regulates SATB1-mediated transcriptional repression."J. Biol. Chem. 280:24600-24609(2005) [PubMed] [Europe PMC] [Abstract]
  18. "Dynein light chain rp3 acts as a nuclear matrix-associated transcriptional modulator in a dynein-independent pathway."J. Cell Sci. 118:3431-3443(2005) [PubMed] [Europe PMC] [Abstract]
  19. "Displacement of SATB1-bound histone deacetylase 1 corepressor by the human immunodeficiency virus type 1 transactivator induces expression of interleukin-2 and its receptor in T cells."Mol. Cell. Biol. 25:1620-1633(2005) [PubMed] [Europe PMC] [Abstract]
  20. "The behavior of SATB1, a MAR-binding protein, in response to apoptosis stimulation."Cell Biol. Int. 30:244-247(2006) [PubMed] [Europe PMC] [Abstract]
  21. "Phosphorylation of SATB1, a global gene regulator, acts as a molecular switch regulating its transcriptional activity in vivo."Mol. Cell 22:231-243(2006) [PubMed] [Europe PMC] [Abstract]
  22. "SATB1-binding sequences and Alu-like motifs define a unique chromatin context in the vicinity of human immunodeficiency virus type 1 integration sites."J. Virol. 81:5617-5627(2007) [PubMed] [Europe PMC] [Abstract]
  23. "Functional interaction between PML and SATB1 regulates chromatin-loop architecture and transcription of the MHC class I locus."Nat. Cell Biol. 9:45-56(2007) [PubMed] [Europe PMC] [Abstract]
  24. "Cellular homeoproteins, SATB1 and CDP, bind to the unique region between the human cytomegalovirus UL127 and major immediate-early genes."Virology 366:117-125(2007) [PubMed] [Europe PMC] [Abstract]
  25. "SUMO conjugation to the matrix attachment region-binding protein, special AT-rich sequence-binding protein-1 (SATB1), targets SATB1 to promyelocytic nuclear bodies where it undergoes caspase cleavage."J. Biol. Chem. 283:18124-18134(2008) [PubMed] [Europe PMC] [Abstract]
  26. "SATB1 reprogrammes gene expression to promote breast tumour growth and metastasis."Nature 452:187-193(2008) [PubMed] [Europe PMC] [Abstract]
  27. "PDZ domain-mediated dimerization and homeodomain-directed specificity are required for high-affinity DNA binding by SATB1."Nucleic Acids Res. 36:2107-2122(2008) [PubMed] [Europe PMC] [Abstract]
  28. "SATB1 regulates beta-like globin genes through matrix related nuclear relocation of the cluster."Biochem. Biophys. Res. Commun. 383:11-15(2009) [PubMed] [Europe PMC] [Abstract]
  29. "SATB1 binds an intronic MAR sequence in human PI3kgamma in vitro."Mol. Biol. Rep. 37:1461-1465(2010) [PubMed] [Europe PMC] [Abstract]
  30. "Acetylation-dependent interaction of SATB1 and CtBP1 mediates transcriptional repression by SATB1."Mol. Cell. Biol. 29:1321-1337(2009) [PubMed] [Europe PMC] [Abstract]
  31. "Inter-MAR association contributes to transcriptionally active looping events in human beta-globin gene cluster."PLoS ONE 4:E4629-E4629(2009) [PubMed] [Europe PMC] [Abstract]
  32. "Solution structure and DNA-binding mode of the matrix attachment region-binding domain of the transcription factor SATB1 that regulates the T-cell maturation."J. Biol. Chem. 281:5319-5327(2006) [PubMed] [Europe PMC] [Abstract]
  33. "Structural basis for recognition of the matrix attachment region of DNA by transcription factor SATB1."Nucleic Acids Res. 35:5073-5084(2007) [PubMed] [Europe PMC] [Abstract]