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SATB Homeobox Protein 2 (SATB2)

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DNA-binding protein SATB2; Special AT-rich sequence-binding protein 2

SATB Homeobox Protein 2 (SATB2)
CCC K005
HGNC 21637
MGI 2679336
RGD 1562369
UniProt Q9UPW6
SATB2 encodes a DNA binding protein that specifically binds nuclear matrix attachment regions. The encoded protein is involved in transcription regulation and chromatin remodeling. Defects in this gene are associated with isolated cleft palate and mental retardation. Alternate splicing results in multiple transcript variants that encode the same protein.
The deduced 761-amino acid protein shares 61% identity with SATB1. RT-PCR ELISA detected high expression in adult brain, moderate expression in fetal brain, and weak expression in adult liver, kidney, and spinal cord and in select brain regions, including amygdala, corpus callosum, caudate nucleus, and hippocampus. Little to no expression was detected in all other tissues and individual brain regions examined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPK005Hu01 Recombinant SATB Homeobox Protein 2 (SATB2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAK005Hu01 Polyclonal Antibody to SATB Homeobox Protein 2 (SATB2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for SATB Homeobox Protein 2 (SATB2) CLIA Kit Customized Service Offer
n/a ELISA Kit for SATB Homeobox Protein 2 (SATB2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SATB Homeobox Protein 2 (SATB2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SATB Homeobox Protein 2 (SATB2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SATB Homeobox Protein 2 (SATB2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SATB Homeobox Protein 2 (SATB2) CLIA Kit Customized Service Offer
n/a ELISA Kit for SATB Homeobox Protein 2 (SATB2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SATB Homeobox Protein 2 (SATB2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SATB Homeobox Protein 2 (SATB2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SATB Homeobox Protein 2 (SATB2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SATB Homeobox Protein 2 (SATB2) CLIA Kit Customized Service Offer
n/a ELISA Kit for SATB Homeobox Protein 2 (SATB2) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "SUMO modification of a novel MAR-binding protein, SATB2, modulates immunoglobulin mu gene expression."Genes Dev. 17:3048-3061(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of SATB2 as the cleft palate gene on 2q32-q33."Hum. Mol. Genet. 12:2491-2501(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Heterozygous nonsense mutation SATB2 associated with cleft palate, osteoporosis, and cognitive defects."Hum. Mutat. 28:732-738(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Toriello-Carey syndrome in a patient with a de novo balanced translocation [46,XY,t(2;14)(q33;q22)] interrupting SATB2."Clin. Genet. 75:259-264(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Solution structure of the homeodomain of KIAA1034 protein."Submitted (FEB-2009) to the PDB data bank
  10. "Solution structure of the first CUT domain of KIAA1034 protein."Submitted (FEB-2009) to the PDB data bank
  11. "Solution structure of the second CUT domain of human SATB2."Submitted (FEB-2009) to the PDB data bank