Orthodenticle Homeobox Protein 2 (OTX2)

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Orthodenticle Homeobox Protein 2 (OTX2)
OTX2 encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. A similar protein in mice is required for proper forebrain development. Two transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants may exist, but their full length sequences have not been determined.Otx2 deficiency converted differentiating photoreceptor cells to amacrine-like neurons, reflecting a change in progenitor cell fate, and led to a total lack of pinealocytes in the pineal gland. Expression studies suggested that Otx2 is a direct upstream regulator of another cone-rod homeobox-containing gene, Crx, via binding to specific consensus sequences in the Crx promoter.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Orthodenticle Homeobox Protein 2 (OTX2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Orthodenticle Homeobox Protein 2 (OTX2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Orthodenticle Homeobox Protein 2 (OTX2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Orthodenticle Homeobox Protein 2 (OTX2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Orthodenticle Homeobox Protein 2 (OTX2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Orthodenticle Homeobox Protein 2 (OTX2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Orthodenticle Homeobox Protein 2 (OTX2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Orthodenticle Homeobox Protein 2 (OTX2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Orthodenticle Homeobox Protein 2 (OTX2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Orthodenticle Homeobox Protein 2 (OTX2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Orthodenticle Homeobox Protein 2 (OTX2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Orthodenticle Homeobox Protein 2 (OTX2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Orthodenticle Homeobox Protein 2 (OTX2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Orthodenticle Homeobox Protein 2 (OTX2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Orthodenticle Homeobox Protein 2 (OTX2) ELISA Kit Customized Service Offer
  1. "A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo."EMBO J. 12:2735-2747(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Elements regulating the transcription of human interstitial retinoid-binding protein (IRBP) gene in cultured retinoblastoma cells."Curr. Eye Res. 18:283-291(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Heterozygous mutations of OTX2 cause severe ocular malformations." Am. J. Hum. Genet. 76:1008-1022(2005) [PubMed] [Europe PMC] [Abstract]
  6. Erratum Am. J. Hum. Genet. 77:334-334(2005)
  7. "Expression of the homeobox genes PAX6, OTX2, and OTX1 in the early human fetal retina."Int. J. Dev. Neurosci. 27:485-492(2009) [PubMed] [Europe PMC] [Abstract]
  8. "A novel dominant negative mutation of OTX2 associated with combined pituitary hormone deficiency."J. Clin. Endocrinol. Metab. 93:4351-4359(2008) [PubMed] [Europe PMC] [Abstract]
  9. "A novel loss-of-function mutation in OTX2 in a patient with anophthalmia and isolated growth hormone deficiency."Hum. Genet. 127:721-729(2010) [PubMed] [Europe PMC] [Abstract]