≡

NANOG Homeobox Protein (NANOG)

[Edit]

Homeobox transcription factor Nanog

NANOG Homeobox Protein (NANOG)
CCC J992
HGNC 20857
MGI 1919200
PubMed 23892456
RGD 1303178
UniProt Q9H9S0
Wiki NANOG
NANOG is a transcription factor critically involved with self-renewal of undifferentiated embryonic stem cells. Human NANOG protein is a 305 amino acid protein with a conserved homeodomain motif that is localized to the nuclear component of cells. The homeodomain region facilitates DNA binding. There are N-terminal, homeodomain, and C-terminal regions in human NANOG protein. Like murine NANOG, N-terminal region of human NANOG is rich in Ser, Thr and Pro residues and C-terminus contains W repeats. The homeodomain in hNANOG ranges from residues 95 to 155. NANOG is a gene expressed in embryonic stem cells (ESCs) and is thought to be a key factor in maintaining pluripotency. NANOG is thought to function in concert with other factors such as POU5F1 and SOX2 to establish ESC identity.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ992Hu01 Recombinant NANOG Homeobox Protein (NANOG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ992Hu01 Polyclonal Antibody to NANOG Homeobox Protein (NANOG) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for NANOG Homeobox Protein (NANOG) CLIA Kit Customized Service Offer
n/a ELISA Kit for NANOG Homeobox Protein (NANOG) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant NANOG Homeobox Protein (NANOG) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to NANOG Homeobox Protein (NANOG) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to NANOG Homeobox Protein (NANOG) Polyclonal Antibody Customized Service Offer
Assay Kits SEJ992Mu ELISA Kit for NANOG Homeobox Protein (NANOG) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant NANOG Homeobox Protein (NANOG) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to NANOG Homeobox Protein (NANOG) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to NANOG Homeobox Protein (NANOG) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for NANOG Homeobox Protein (NANOG) CLIA Kit Customized Service Offer
n/a ELISA Kit for NANOG Homeobox Protein (NANOG) ELISA Kit Customized Service Offer
  1. "The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells."Cell 113:631-642(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Human STELLAR, NANOG, and GDF3 genes are expressed in pluripotent cells and map to chromosome 12p13, a hotspot for teratocarcinoma."Stem Cells 22:169-179(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Identification and functional characterization of an alternative splice variant within the fourth exon of human nanog."Exp. Mol. Med. 37:601-607(2005) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells."Cell 113:643-655(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Identification, cloning and expression analysis of the pluripotency promoting Nanog genes in mouse and human."Dev. Dyn. 230:187-198(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of a putative transactivation domain in human Nanog."Exp. Mol. Med. 37:250-254(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Stem cell pluripotency factor NANOG is expressed in human fetal gonocytes, testicular carcinoma in situ and germ cell tumours."Histopathology 47:48-56(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Pluripotential competence of cells associated with Nanog activity."Mech. Dev. 122:67-79(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Downregulation of NANOG induces differentiation of human embryonic stem cells to extraembryonic lineages."Stem Cells 23:1035-1043(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Solution structure of human stem cell transcription factor NANOG."Submitted (MAR-2010) to the PDB data bank
  12. "Eleven daughters of NANOG."Genomics 84:229-238(2004) [PubMed] [Europe PMC] [Abstract]