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Hematopoietic Lineage Cell Specific Protein (HCLS1)

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HS1; CTTNL; LckBP1; p75; Hematopoietic Cell-Specific Lyn Substrate 1; Cortactin-Like

Hematopoietic Lineage Cell Specific Protein (HCLS1)
CCC J968
HGNC 4844
MGI 104568
PubMed 23001182
RGD 1304754
UniProt P14317
Wiki HCLS1
Sequence analysis predicted that the 486-amino acid hydrophilic protein lacks a signal peptide, N-glycosylation sites, and a transmembrane region, but contains several potential phosphorylation sites. HCLS1 has an N-terminal series of at least three 37-amino acid repeats, each of which includes 2 alpha helices, that are called HS1 repeats and are also found in contactin (CNTN1).
In addition, HCLS1 has a central region homologous to the adenovirus E1A probe and a C-terminal SH3 domain. Northern blot analysis revealed expression of a 2.0-kb HCLS1 transcript restricted to hemopoietic tissues and cell lines. Western blot analysis showed expression of a 75-kD protein, considerably larger than the predicted 54 kD.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Hematopoietic Lineage Cell Specific Protein (HCLS1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Hematopoietic Lineage Cell Specific Protein (HCLS1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Hematopoietic Lineage Cell Specific Protein (HCLS1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Hematopoietic Lineage Cell Specific Protein (HCLS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hematopoietic Lineage Cell Specific Protein (HCLS1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Hematopoietic Lineage Cell Specific Protein (HCLS1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Hematopoietic Lineage Cell Specific Protein (HCLS1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Hematopoietic Lineage Cell Specific Protein (HCLS1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Hematopoietic Lineage Cell Specific Protein (HCLS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hematopoietic Lineage Cell Specific Protein (HCLS1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Hematopoietic Lineage Cell Specific Protein (HCLS1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Hematopoietic Lineage Cell Specific Protein (HCLS1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Hematopoietic Lineage Cell Specific Protein (HCLS1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Hematopoietic Lineage Cell Specific Protein (HCLS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hematopoietic Lineage Cell Specific Protein (HCLS1) ELISA Kit Customized Service Offer
  1. "Isolation and characterization of a novel human gene expressed specifically in the cells of hematopoietic lineage."Nucleic Acids Res. 17:9367-9379(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Identification of HS1 protein as a major substrate of protein-tyrosine kinase(s) upon B-cell antigen receptor-mediated signaling."Proc. Natl. Acad. Sci. U.S.A. 90:3631-3635(1993) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of the 70kD heat shock cognate protein (Hsc70) and alpha-actinin-1 as novel phosphotyrosine-containing proteins in T lymphocytes."Biochem. Biophys. Res. Commun. 224:666-674(1996) [PubMed] [Europe PMC] [Abstract]
  7. "SH2 domains mediate the sequential phosphorylation of HS1 protein by p72syk and Src-related protein tyrosine kinases."Biochemistry 35:5327-5332(1996) [PubMed] [Europe PMC] [Abstract]
  8. "HAX-1, a novel intracellular protein, localized on mitochondria, directly associates with HS1, a substrate of Src family tyrosine kinases."J. Immunol. 158:2736-2744(1997) [PubMed] [Europe PMC] [Abstract]
  9. "Molecular features underlying the sequential phosphorylation of HS1 protein and its association with c-Fgr protein-tyrosine kinase."J. Biol. Chem. 274:7557-7564(1999) [PubMed] [Europe PMC] [Abstract]
  10. "Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry."Proc. Natl. Acad. Sci. U.S.A. 100:443-448(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]