≡

Potassium Voltage Gated Channel Shaker Related Subfamily, Member 2 (KCNA2)

[Edit]

HK4; HBK5; HUKIV; KV1.2; MK2; NGK1; RBK2; Voltage-gated potassium channel subunit Kv1.2

Potassium Voltage Gated Channel Shaker Related Subfamily, Member 2 (KCNA2)
CCC J958
HGNC 6220
MGI 96659
PubMed 22342001
RGD 2950
UniProt P16389
Wiki KCNA2
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four
KCNA2 encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Potassium Voltage Gated Channel Shaker Related Subfamily, Member 2 (KCNA2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Potassium Voltage Gated Channel Shaker Related Subfamily, Member 2 (KCNA2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Potassium Voltage Gated Channel Shaker Related Subfamily, Member 2 (KCNA2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Potassium Voltage Gated Channel Shaker Related Subfamily, Member 2 (KCNA2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Potassium Voltage Gated Channel Shaker Related Subfamily, Member 2 (KCNA2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Potassium Voltage Gated Channel Shaker Related Subfamily, Member 2 (KCNA2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Potassium Voltage Gated Channel Shaker Related Subfamily, Member 2 (KCNA2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Potassium Voltage Gated Channel Shaker Related Subfamily, Member 2 (KCNA2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Potassium Voltage Gated Channel Shaker Related Subfamily, Member 2 (KCNA2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Potassium Voltage Gated Channel Shaker Related Subfamily, Member 2 (KCNA2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Potassium Voltage Gated Channel Shaker Related Subfamily, Member 2 (KCNA2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Potassium Voltage Gated Channel Shaker Related Subfamily, Member 2 (KCNA2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Potassium Voltage Gated Channel Shaker Related Subfamily, Member 2 (KCNA2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Potassium Voltage Gated Channel Shaker Related Subfamily, Member 2 (KCNA2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Potassium Voltage Gated Channel Shaker Related Subfamily, Member 2 (KCNA2) ELISA Kit Customized Service Offer
  1. "Human potassium channel genes: molecular cloning and functional expression."Mol. Cell. Neurosci. 1:214-223(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract].
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Heteromultimeric assembly of human potassium channels. Molecular basis of a transient outward current?"Circ. Res. 72:1326-1336(1993) [PubMed] [Europe PMC] [Abstract]
  6. "Caspr2, a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K+ channels."Neuron 24:1037-1047(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Role of receptor protein tyrosine phosphatase alpha (RPTPalpha) and tyrosine phosphorylation in the serotonergic inhibition of voltage-dependent potassium channels."Pflugers Arch. 441:257-262(2000) [PubMed] [Europe PMC] [Abstract]
  8. "Subunit composition and novel localization of K+ channels in spinal cord."J. Comp. Neurol. 429:166-176(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Voltage-gated ion channels in the axon initial segment of human cortical pyramidal cells and their relationship with chandelier cells."Proc. Natl. Acad. Sci. U.S.A. 103:2920-2925(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Ionic channel function in action potential generation: current perspective."Mol. Neurobiol. 35:129-150(2007) [PubMed] [Europe PMC] [Abstract]
  11. "The molecular basis for the actions of Kvbeta1.2 on the opening and closing of the Kv1.2 delayed rectifier channel."Channels 3:314-322(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Biochemical characterization of kappaM-RIIIJ, a Kv1.2 channel blocker: evaluation of cardioprotective effects of kappaM-conotoxins."J. Biol. Chem. 285:14882-14889(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Altered distribution of juxtaparanodal kv1.2 subunits mediates peripheral nerve hyperexcitability in type 2 diabetes mellitus."J. Neurosci. 32:7493-7498(2012) [PubMed] [Europe PMC] [Abstract]
  14. "Activation of lysophosphatidic acid receptor by gintonin inhibits Kv1.2 channel activity: involvement of tyrosine kinase and receptor protein tyrosine phosphatase alpha."Neurosci. Lett. 548:143-148(2013) [PubMed] [Europe PMC] [Abstract]