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Interleukin 1 Receptor Like Protein 2 (IL1RL2)

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IL1R-rp2; IL1RRP2; IL-36 receptor; Interleukin-1 receptor-related protein 2

Interleukin 1 Receptor Like Protein 2 (IL1RL2)
CCC J945
HGNC 5999
MGI 1913107
PubMed 10191101
RGD 621782
UniProt Q9HB29
Wiki IL1RL2
IL1RL2 is a member of the interleukin 1 receptor family. An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. This gene and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1), and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.
IL1RRP2, that encodes a 561-amino acid protein with significant sequence identity to IL1R1.like IL1RRP , IL1RRP2 failed to bind IL1-alpha or IL1-beta.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Interleukin 1 Receptor Like Protein 2 (IL1RL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Interleukin 1 Receptor Like Protein 2 (IL1RL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interleukin 1 Receptor Like Protein 2 (IL1RL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interleukin 1 Receptor Like Protein 2 (IL1RL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interleukin 1 Receptor Like Protein 2 (IL1RL2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Interleukin 1 Receptor Like Protein 2 (IL1RL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Interleukin 1 Receptor Like Protein 2 (IL1RL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interleukin 1 Receptor Like Protein 2 (IL1RL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interleukin 1 Receptor Like Protein 2 (IL1RL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interleukin 1 Receptor Like Protein 2 (IL1RL2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Interleukin 1 Receptor Like Protein 2 (IL1RL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Interleukin 1 Receptor Like Protein 2 (IL1RL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interleukin 1 Receptor Like Protein 2 (IL1RL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interleukin 1 Receptor Like Protein 2 (IL1RL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interleukin 1 Receptor Like Protein 2 (IL1RL2) ELISA Kit Customized Service Offer
  1. "Identification and characterization of two members of a novel class of the interleukin-1 receptor (IL-1R) family. Delineation of a new class of IL-1R-related proteins based on signaling."J. Biol. Chem. 275:29946-29954(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL1R-rp2)."J. Neuroimmunol. 70:113-122(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2."J. Immunol. 167:1440-1446(2001) [PubMed] [Europe PMC] [Abstract]
  6. "The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes."Arthritis Res. Ther. 8:R80-R80(2006) [PubMed] [Europe PMC] [Abstract]
  7. "IL-36 promotes myeloid cell infiltration, activation, and inflammatory activity in skin."J. Immunol. 192:6053-6061(2014) [PubMed] [Europe PMC] [Abstract]