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Makorin Ring Finger Protein 3 (MKRN3)

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ZNF127; D15S9; RNF63; ZFP127; Zinc Finger Protein 127; Probable E3 ubiquitin-protein ligase makorin-3

Makorin Ring Finger Protein 3 (MKRN3)
CCC J921
HGNC 7114
MGI 2181178
PubMed 23738509
RGD 1311197
UniProt Q13064
The ZNF127 gene encodes a 507-amino acid protein with a RING (C3HC4) zinc finger motif and multiple C3H zinc finger motifs, the former being closely related to a protein from variola major virus, the smallpox etiologic agent. These motifs predict ribonucleoprotein function for the ZNF127 polypeptide.
Northern blot analysis revealed that the intronless ZNF127 gene is expressed ubiquitously as an approximately 3-kb transcript; however, the entire coding sequence and 5-prime CpG island overlap a second gene, ZNF127AS, which is transcribed from the antisense strand with a different transcript size and pattern of expression. Allele-specific analysis showed that the ZNF127 gene is expressed only from the paternal allele.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Makorin Ring Finger Protein 3 (MKRN3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Makorin Ring Finger Protein 3 (MKRN3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Makorin Ring Finger Protein 3 (MKRN3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Makorin Ring Finger Protein 3 (MKRN3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Makorin Ring Finger Protein 3 (MKRN3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Makorin Ring Finger Protein 3 (MKRN3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Makorin Ring Finger Protein 3 (MKRN3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Makorin Ring Finger Protein 3 (MKRN3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Makorin Ring Finger Protein 3 (MKRN3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Makorin Ring Finger Protein 3 (MKRN3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Makorin Ring Finger Protein 3 (MKRN3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Makorin Ring Finger Protein 3 (MKRN3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Makorin Ring Finger Protein 3 (MKRN3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Makorin Ring Finger Protein 3 (MKRN3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Makorin Ring Finger Protein 3 (MKRN3) ELISA Kit Customized Service Offer
  1. "A novel imprinted gene, encoding a RING zinc-finger protein, and overlapping antisense transcript in the Prader-Willi syndrome critical region."Hum. Mol. Genet. 8:783-793(1999) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "A paternal deletion of MKRN3, MAGEL2 and NDN does not result in Prader-Willi syndrome."Eur. J. Hum. Genet. 17:582-590(2009) [PubMed] [Europe PMC] [Abstract]
  4. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Central precocious puberty caused by mutations in the imprinted gene MKRN3." N. Engl. J. Med. 368:2467-2475(2013) [PubMed] [Europe PMC] [Abstract]
  6. "MKRN3 mutations in familial central precocious puberty."Horm. Res. Paediatr. 82:122-126(2014) [PubMed] [Europe PMC] [Abstract]
  7. "A novel MKRN3 missense mutation causing familial precocious puberty."Hum. Reprod. 29:2838-2843(2014) [PubMed] [Europe PMC] [Abstract]
  8. "Central precocious puberty in a girl and early puberty in her brother caused by a novel mutation in the MKRN3 gene."J. Clin. Endocrinol. Metab. 99:E647-651(2014) [PubMed] [Europe PMC] [Abstract]
  9. "Central precocious puberty that appears to be sporadic caused by paternally inherited mutations in the imprinted gene makorin ring finger 3." J. Clin. Endocrinol. Metab. 99:E1097-1103(2014) [PubMed] [Europe PMC] [Abstract]