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Makorin Ring Finger Protein 1 (MKRN1)

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RNF61; E3 ubiquitin-protein ligase makorin-1; RING finger protein 61

Makorin Ring Finger Protein 1 (MKRN1)
CCC J919
HGNC 7112
MGI 1859353
PubMed 16785614
UniProt Q9UHC7
The human MKRN1 cDNA contains a contiguous sequence of 3,026 basepairs including an open reading frame (ORF) from nucleotide 121 to 1567 that encodes a putative protein of 482 amino acids. Mouse and Drosophila
Mkrn1 proteins share 92% and 27% with the human protein, respectively, with Drosophila Mkrn1 reaching 63% identity over 123 amino acids spanning from upstream of the RING finger through the C-terminal C3H zinc finger. Northern blot analysis of human tissues detected a single prominent 3.2-kb transcript, suggesting that the MKRN1 gene is highly and uniformly expressed in all tissues, including different regions of the brain. High levels were observed in murine embryonic nervous system and adult testis.MKRN1 interacts with a C-terminal domain of TERT, the catalytic subunit of the telomerase ribonucleoprotein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Makorin Ring Finger Protein 1 (MKRN1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Makorin Ring Finger Protein 1 (MKRN1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Makorin Ring Finger Protein 1 (MKRN1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Makorin Ring Finger Protein 1 (MKRN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Makorin Ring Finger Protein 1 (MKRN1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Makorin Ring Finger Protein 1 (MKRN1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Makorin Ring Finger Protein 1 (MKRN1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Makorin Ring Finger Protein 1 (MKRN1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Makorin Ring Finger Protein 1 (MKRN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Makorin Ring Finger Protein 1 (MKRN1) ELISA Kit Customized Service Offer
  1. "The ancient source of a distinct gene family encoding proteins featuring RING and C(3)H zinc-finger motifs with abundant expression in developing brain and nervous system."Genomics 66:76-86(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Human chromosome 7: DNA sequence and biology." Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Ubiquitin ligase MKRN1 modulates telomere length homeostasis through a proteolysis of hTERT."Genes Dev. 19:776-781(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Makorin RING finger protein 1 (MKRN1) has negative and positive effects on RNA polymerase II-dependent transcription."Endocrine 29:363-373(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Identification of Makorin 1 as a novel SEREX antigen of esophageal squamous cell carcinoma."BMC Cancer 9:232-232(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis."EMBO J. 28:2100-2113(2009) [PubMed] [Europe PMC] [Abstract]