Cardiomyopathy Associated Protein 5 (CMYA5)

Myospryn is a muscle-specific protein kinase A (PKA)-anchoring protein that is dysregulated in Duchenne muscular dystrophy (DMD).

The deduced 3,739-amino acid protein has an N-terminal region containing 19 imperfect 12-amino acid repeats, followed by 2 BBox-like domains, a coiled-coil BBC domain, 2 FN3 domains , and a SPRY domain. Northern blot analysis detected myospryn in heart, skeletal muscle, and skin. Western blot analysis detected myospryn in heart and skeletal muscle. In rat muscle sarcolemma and sarcoplasm, myospryn colocalized with dysbindin (DTNBP1), a protein that associates with the dystrobrevin-glycoprotein complex, and both proteins cofractionated with microsomal membranes.