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Coiled Coil Domain Containing Protein 88C (CCDC88C)

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DAPLE; HkRP2; Dvl-Associating Protein With A High Frequency Of Leucine Residues; Hook-related protein 2

Coiled Coil Domain Containing Protein 88C (CCDC88C)
CCC J902
HGNC 19967
MGI 1915589
PubMed 23042809
RGD 1307429
UniProt Q9P219
Based on in silico analysis, Simpson et al. (2005) found that CCDC88C, which they called HKRP2, encodes a deduced 2,028-amino acid protein with sequence similarity to HKRP1.
The deduced 2,009-amino acid protein was high in leucine residues, leading the authors to name the protein Daple. the C terminus of Daple was necessary for binding to the PDZ domain of Dvl. When expressed in mouse fibroblasts, Daple inhibited Wnt3a-induced accumulation of beta-catenin as well as the Wnt3a-dependent activation of T-cell factor (Tcf) transcription. Daple expression in Xenopus embryos inhibited axis formation, another process regulated by the Wnt signaling pathway.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Coiled Coil Domain Containing Protein 88C (CCDC88C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Coiled Coil Domain Containing Protein 88C (CCDC88C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Coiled Coil Domain Containing Protein 88C (CCDC88C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Coiled Coil Domain Containing Protein 88C (CCDC88C) CLIA Kit Customized Service Offer
n/a ELISA Kit for Coiled Coil Domain Containing Protein 88C (CCDC88C) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Coiled Coil Domain Containing Protein 88C (CCDC88C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Coiled Coil Domain Containing Protein 88C (CCDC88C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Coiled Coil Domain Containing Protein 88C (CCDC88C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Coiled Coil Domain Containing Protein 88C (CCDC88C) CLIA Kit Customized Service Offer
n/a ELISA Kit for Coiled Coil Domain Containing Protein 88C (CCDC88C) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Coiled Coil Domain Containing Protein 88C (CCDC88C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Coiled Coil Domain Containing Protein 88C (CCDC88C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Coiled Coil Domain Containing Protein 88C (CCDC88C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Coiled Coil Domain Containing Protein 88C (CCDC88C) CLIA Kit Customized Service Offer
n/a ELISA Kit for Coiled Coil Domain Containing Protein 88C (CCDC88C) ELISA Kit Customized Service Offer
  1. "Kits, such as nucleic acid arrays, comprising a majority of human exons or transcripts, for detecting expression and other uses thereof."Patent number WO02068579, 06-SEP-2002
  2. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract].
  4. "Full-length cDNA libraries and normalization."Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
  5. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
  6. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  7. "A novel hook-related protein family and the characterization of hook-related protein 1."Traffic 6:442-458(2005) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Disturbed Wnt signalling due to a mutation in CCDC88C causes an autosomal recessive non-syndromic hydrocephalus with medial diverticulum."Mol. Syndromol. 1:99-112(2010) [PubMed] [Europe PMC] [Abstract]
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Two novel CCDC>88C mutations confirm the role of DAPLE in autosomal recessive congenital hydrocephalus."J. Med. Genet. 49:708-712(2012) [PubMed] [Europe PMC] [Abstract]
  13. "A novel missense mutation in CCDC88C activates the JNK pathway and causes a dominant form of spinocerebellar ataxia."J. Med. Genet. 51:590-595(2014) [PubMed] [Europe PMC] [Abstract]