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Golgi Associated PDZ And Coiled Coil Motif Containing Protein (GOPC)

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FIG; CAL; GOPC1; PIST; CFTR-associated ligand; Fused in glioblastoma; PDZ protein interacting specifically with TC10

Golgi Associated PDZ And Coiled Coil Motif Containing Protein (GOPC)
CCC J899
HGNC 17643
MGI 2149946
PubMed 11162552
RGD 1309512
UniProt Q9HD26
Wiki GOPC
PIST is a PDZ domain-containing Golgi protein. PDZ domains contain approximately 90 amino acids and bind the extreme C terminus of proteins in a sequence-specific manner.
The deduced 454-amino acid human protein, which is approximately 92% identical to the mouse protein, contains 2 putative coiled-coil domains, with a potential leucine zipper in the second domain, followed by a novel region conserved in mouse and worm, and a PDZ domain. Northern blot analysis revealed ubiquitous expression of a 4.4-kb transcript, with highest expression in brain and heart.Coimmunoprecipitation and colocalization experiments demonstrated that the specific interaction of Grid2 and nPist requires the C terminus of Grid2 and the nPist PDZ domain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Golgi Associated PDZ And Coiled Coil Motif Containing Protein (GOPC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Golgi Associated PDZ And Coiled Coil Motif Containing Protein (GOPC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Golgi Associated PDZ And Coiled Coil Motif Containing Protein (GOPC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Golgi Associated PDZ And Coiled Coil Motif Containing Protein (GOPC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Golgi Associated PDZ And Coiled Coil Motif Containing Protein (GOPC) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Golgi Associated PDZ And Coiled Coil Motif Containing Protein (GOPC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Golgi Associated PDZ And Coiled Coil Motif Containing Protein (GOPC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Golgi Associated PDZ And Coiled Coil Motif Containing Protein (GOPC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Golgi Associated PDZ And Coiled Coil Motif Containing Protein (GOPC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Golgi Associated PDZ And Coiled Coil Motif Containing Protein (GOPC) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Golgi Associated PDZ And Coiled Coil Motif Containing Protein (GOPC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Golgi Associated PDZ And Coiled Coil Motif Containing Protein (GOPC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Golgi Associated PDZ And Coiled Coil Motif Containing Protein (GOPC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Golgi Associated PDZ And Coiled Coil Motif Containing Protein (GOPC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Golgi Associated PDZ And Coiled Coil Motif Containing Protein (GOPC) ELISA Kit Customized Service Offer
  1. "PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10."Biochem. Biophys. Res. Commun. 280:541-547(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Association of a novel PDZ domain-containing peripheral Golgi protein with the Q-SNARE (Q-soluble N-ethylmaleimide-sensitive fusion protein (NSF) attachment protein receptor) protein syntaxin 6."J. Biol. Chem. 276:29456-29465(2001) [PubMed] [Europe PMC] [Abstract]
  3. "A Golgi-associated PDZ domain protein modulates cystic fibrosis transmembrane regulator plasma membrane expression."J. Biol. Chem. 277:3520-3529(2002) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21)."Genes Chromosomes Cancer 37:58-71(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Modulation of mature cystic fibrosis transmembrane regulator protein by the PDZ domain protein CAL."J. Biol. Chem. 279:1892-1898(2004) [PubMed] [Europe PMC] [Abstract]
  9. "PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current."J. Biol. Chem. 279:46962-46968(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Interaction with cystic fibrosis transmembrane conductance regulator-associated ligand (CAL) inhibits beta1-adrenergic receptor surface expression."J. Biol. Chem. 279:50190-50196(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Regulation of cystic fibrosis transmembrane regulator trafficking and protein expression by a Rho family small GTPase TC10."J. Biol. Chem. 280:3731-3739(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Isoform-specific interaction of golgin-160 with the Golgi-associated protein PIST."J. Biol. Chem. 280:28944-28951(2005) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  15. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  17. "Solution structure of GOPC PDZ domain and its interaction with the C-terminal motif of neuroligin."Protein Sci. 15:2149-2158(2006) [PubMed] [Europe PMC] [Abstract]