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Bromodomain And WD Repeat Containing Protein 2 (BRWD2)

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WDR11; DR11; WDR15; WD Repeat Domain 11

Bromodomain And WD Repeat Containing Protein 2 (BRWD2)
CCC J894
HGNC 13831
MGI 1920230
PubMed 10718198
RGD 1587347
UniProt Q9BZH6
Wiki BRWD2
BRWD2 encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation.
This gene is located in the chromosome 10q25-26 region, which is frequently deleted in gliomas and tumors of other tissues, and is disrupted by the t(10;19) translocation rearrangement in glioblastoma cells. The gene location suggests that it is a candidate gene for the tumor suppressor locus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Bromodomain And WD Repeat Containing Protein 2 (BRWD2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Bromodomain And WD Repeat Containing Protein 2 (BRWD2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Bromodomain And WD Repeat Containing Protein 2 (BRWD2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Bromodomain And WD Repeat Containing Protein 2 (BRWD2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Bromodomain And WD Repeat Containing Protein 2 (BRWD2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Bromodomain And WD Repeat Containing Protein 2 (BRWD2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Bromodomain And WD Repeat Containing Protein 2 (BRWD2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Bromodomain And WD Repeat Containing Protein 2 (BRWD2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Bromodomain And WD Repeat Containing Protein 2 (BRWD2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Bromodomain And WD Repeat Containing Protein 2 (BRWD2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Bromodomain And WD Repeat Containing Protein 2 (BRWD2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Bromodomain And WD Repeat Containing Protein 2 (BRWD2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Bromodomain And WD Repeat Containing Protein 2 (BRWD2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Bromodomain And WD Repeat Containing Protein 2 (BRWD2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Bromodomain And WD Repeat Containing Protein 2 (BRWD2) ELISA Kit Customized Service Offer
  1. "A novel member of the WD-repeat gene family, WDR11, maps to the 10q26 region and is disrupted by a chromosome translocation in human glioblastoma cells."Oncogene 20:5378-5392(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "WDR11, a WD protein that interacts with transcription factor EMX1, is mutated in idiopathic hypogonadotropic hypogonadism and Kallmann syndrome." Am. J. Hum. Genet. 87:465-479(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]